Strontium-catalyzed highly enantioselective Michael additions of malonates to enones
Strontium-catalyzed highly enantioselective Michael additions of malonates to enones
复制标题
DOI：
10.1021/ja710332h
复制
发表时间：
2008-02-27
影响因子：
15
通讯作者：
Kobayashi, Shu
中科院分区：
文献类型：
--
作者：
Agostinho, Magno;Kobayashi, Shu
开发了一种基于手性锶络合物的新型催化剂体系，该体系可促进丙二酸酯与烯酮的催化不对称迈克尔加成反应。共轭加成反应在 5 mol% 手性锶催化剂存在下在室温下顺利进行，以高收率和优异的对映选择性提供所需的加合物。该方法提供了一个.制备具有各种官能团和进一步功能化的可能位点的构建块的有效方法。
A novel catalyst system based on a chiral strontium complex which promotes the catalytic asymmetric Michael addition reactions of malonates to enones has been developed. The conjugate addition reactions proceeded smoothly in the presence of 5 mol % of the chiral strontium catalyst, at room temperature, to afford the desired adducts in high yields and excellent enantioselectivities. This method provides an. efficient approach to the preparation of building blocks possessing various functional groups and possible sites for further functionalization.