Correlation Between HLA Alleles and EGFR Mutation in Japanese Patients with Adenocarcinoma of the Lung
Correlation Between HLA Alleles and EGFR Mutation in Japanese Patients with Adenocarcinoma of the Lung
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DOI：
10.1097/jto.0b013e3181e0b993
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发表时间：
2010-08-01
影响因子：
20.4
通讯作者：
Yasumoto, Kosei
中科院分区：
文献类型：
--
作者：
Uramoto, Hidetaka;So, Tomoko;Yasumoto, Kosei
介绍：表皮生长因子受体（EGFR）基因激活突变的鉴定是肺癌研究领域最有趣的最新发现之一，它们更常见于女性、从不/轻度吸烟者和东亚患者的腺癌。为什么这样的某些患者容易发展的EGFR突变tumors.Methods：本研究评估了437例肺腺癌患者的病历进行了手术切除。EGFR基因的遗传状态通过聚合酶链反应为基础的分析进行了研究。采用淋巴细胞微量细胞毒试验或聚合酶链反应-序列特异性寡核苷酸进行组织相容性白细胞抗原（HLA）I类血清学分型，并分析EGFR突变与HLA等位基因的相关性。在女性肺腺癌患者中，EGFR突变的发生率在HLA-A2（+）和A2（-）患者中分别为61.0%和41.7%（p = 0.008）。EGFR突变在女性HLA-A2患者中更常见。然而，没有显着的相关性之间的频率被确定为其他HLA等位基因和EGFR突变在同一patientsgroup.Conclusions：EGFR突变与HLA-A2在女性肺腺癌患者。需要进一步的研究来阐明EGFR突变肺癌组织发生中的其他相关因素。
Introduction: The identification of activating mutations in the epidermal growth factor receptor (EGFR) gene is one of the most intriguing recent discoveries in the field of lung cancer research, and they are more commonly found in adenocarcinoma occurring in females, never/light smokers, and East Asian patients. Why such certain patients are susceptible to the development of EGFR-mutant tumors is currently unknown.Methods: This study evaluated the medical records of 437 patients with adenocarcinoma of the lung who underwent a surgical resection. The genetic status of the EGFR gene was investigated by polymerase chain reaction-based analyses. The serological typing of histocompatibility leukocyte antigen (HLA) class I was performed using a microcytotoxicity test of lymphocytes or polymerase chain reaction-sequence-specific oligonucleotides, and the correlation between the EGFR mutation and HLA alleles was analyzed.Results: An EGFR mutation was found more frequently in females and never/former smokers than their counterpart. In females, the incidences of EGFR mutation were 61.0% and 41.7% in HLA-A2 (+) and A2 (-) patients with adenocarcinoma of the lung, respectively (p = 0.008). The EGFR mutation was found more frequently in female patients with HLA-A2. However, no significant correlation was identified between the frequencies of other HLA alleles and EGFR mutations in the same patients group.Conclusions: EGFR mutations are associated with HLA-A2 in female patients with adenocarcinoma of the lung. Further research was needed to elucidate the other relevant factors in the histogenesis of lung cancer with an EGFR mutation.