Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study
Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study
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DOI：
10.1016/s0140-6736(14)61684-6
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发表时间：
2015-05-30
期刊：
影响因子：
168.9
通讯作者：
Pedersen, Marianne Giortz
中科院分区：
文献类型：
--
作者：
Dalsgaard, Soren;Ostergaard, Soren Dinesen;Pedersen, Marianne Giortz
背景：注意缺陷多动障碍（ADHD）是一种常见的精神障碍，与可能增加死亡率的因素有关，如对立违抗性障碍或行为障碍、犯罪、事故和药物滥用。然而，ADHD本身是否与死亡率增加有关尚不清楚。我们的目的是评估大量丹麦个体的adhd相关死亡率。方法通过使用丹麦国家登记册，我们随访了192万人，其中包括32061名ADHD患者，从他们的第一个生日到2013年。我们通过泊松回归估计死亡率比（MRRs），对日历年、年龄、性别、精神疾病家族史、父母年龄、父母教育和就业状况进行调整，以比较有和没有多动症的个体。在随访期间（2490万人年），5580名队列成员死亡。ADHD患者的死亡率为每1万人年5.85人，而非ADHD患者的死亡率为2.21人(完全校正后MRR为2.07,95% CI为1.70-2.50
Background Attention deficit hyperactivity disorder (ADHD) is a common mental disorder associated with factors that are likely to increase mortality, such as oppositional defiant disorder or conduct disorder, criminality, accidents, and substance misuse. However, whether ADHD itself is associated with increased mortality remains unknown. We aimed to assess ADHD-related mortality in a large cohort of Danish individuals.Methods By use of the Danish national registers, we followed up 1.92 million individuals, including 32 061 with ADHD, from their first birthday through to 2013. We estimated mortality rate ratios (MRRs), adjusted for calendar year, age, sex, family history of psychiatric disorders, maternal and paternal age, and parental educational and employment status, by Poisson regression, to compare individuals with and without ADHD.Findings During follow-up (24.9 million person-years), 5580 cohort members died. The mortality rate per 10 000 person-years was 5.85 among individuals with ADHD compared with 2.21 in those without (corresponding to a fully adjusted MRR of 2.07, 95% CI 1.70-2.50; p