Application of density similarities to predict membrane protein types based on pseudo-amino acid composition.
Application of density similarities to predict membrane protein types based on pseudo-amino acid composition.
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DOI：
10.1016/j.jtbi.2011.01.048
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发表时间：
2011-05-07
影响因子：
2
通讯作者：
Jahandideh S
中科院分区：
文献类型：
--
作者：
Mahdavi A;Jahandideh S
细胞膜提供活细胞的完整性。虽然生物膜的稳定性是由脂质双分子层来维持的，但膜蛋白执行大多数特定的功能，如信号转导、跨膜转运等，因此膜蛋白是有吸引力的药物靶点。本文基于用伪氨基酸组成来定义蛋白质的概念，提出了三种不同密度的相似度来预测膜蛋白的类型。预测结果表明，该方法可以显著提高预测精度，并可能成为一个有用的工具，预测蛋白质的其他属性。
Cell membranes provide integrity of living cells. Although the stability of biological membrane is maintained by the lipid bilayer, membrane proteins perform most of the specific functions such as signal transduction, transmembrane transport, etc. Then it is plausible membrane proteins being attractive drug targets. In this article, based on the concept of using the pseudo-amino acid composition to define a protein, three different density similarities are developed for predicting the membrane protein type. The predicted results showed that the proposed approach can remarkably improve the accuracy, and might become a useful tool for predicting the other attributes of proteins as well.