Transneuronal retrograde degeneration of retinal ganglion cells following restricted lesions of striate cortex in the monkey
Transneuronal retrograde degeneration of retinal ganglion cells following restricted lesions of striate cortex in the monkey
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DOI：
10.1007/s002210000384
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发表时间：
2000-05-01
影响因子：
2
通讯作者：
Cowey, A
中科院分区：
文献类型：
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作者：
Johnson, H;Cowey, A
恒河猴广泛切除纹状皮质后视网膜神经节细胞发生跨神经元退行性变性。其程度取决于手术时猴的年龄、术后存活率、物种和视网膜偏心率。对枕叶损伤患者的一些研究没有发现跨神经元退行性变的证据，这表明可能不会发生退行性变，或者如果存在退行性变，则是由于继发性损伤直接影响了下方的白色物质或背外侧膝状体核和视束的血液供应。因此，我们研究了视网膜神经节细胞变性的三只猕猴，其中只有纹状皮质对应：黄斑视网膜已被删除，从而保留外纹沟，并排除中断的血管供应丘脑和视束。在中央视网膜中存在广泛的神经节细胞损失，对应于中央10度视力。由于皮质病变太小，不能直接影响丘脑或视束，因此视网膜变性必须是跨神经元的。定量分析显示，在相应的中央凹周围视网膜沿水平子午线沿着的神经节细胞损失65-80%。结果：证实视网膜神经节细胞的损失后，纹状皮质病变主要是跨神经元。
Transneuronal retrograde degeneration of retinal ganglion cells follows extensive striate cortical removal in macaque monkeys. Its extent depends on the age of the monkey at operation, post-operative survival, species and retinal eccentricity. Some studies of human patients with occipital lobe injury have found no evidence transneuronal retrograde degeneration, suggesting that either degeneration may not occur or, if present, it is caused directly by secondary damage impinging upon the underlying white matter or the blood supply to the dorsal lateral geniculate nucleus and optic tract. We therefore studied retinal ganglion cell degeneration in three macaques in which only the striate cortex corresponding: to the macular retina had been removed, thereby sparing extrastriate colter and precluding interruption of the vascular supply to the thalamus and optic tract. There was extensive loss of ganglion cells in the central retina, corresponding to the central 10 degrees of vision. As the cortical lesion was too small to affect the thalamus or optic tract directly, the retinal degeneration must he transneuronal. Quantitative analysis showed a 65-80% loss of ganglion cells in the corresponding perifoveal retinae along the horizontal meridian. The results: confirm that the loss of retinal gan linn cells following striate cortical lesions is predominantly transneuronal.