The new MTV generation: Using methamphetamine, Truvada™, and Viagra™ to enhance sex and stay safe
The new MTV generation: Using methamphetamine, Truvada™, and Viagra™ to enhance sex and stay safe
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DOI：
10.1016/j.drugpo.2018.02.021
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发表时间：
2018-05-01
影响因子：
4.4
通讯作者：
Prestage, Garrett
中科院分区：
文献类型：
--
作者：
Hammoud, Mohamed A.;Vaccher, Stefanie;Prestage, Garrett
简介：男同性恋者和双性恋者(GBM)经常使用非法药物来增强性快感，通常被称为“化学性行为”或“派对和游戏”。特别是，甲基苯丙胺和伟哥(商标)以及其他勃起功能障碍药物的使用，无论是一起还是单独使用，都对随后的艾滋病毒感染具有强烈的预测作用。Truvada(TM)作为暴露前预防(PrEP)，几乎消除了无套肛交期间的艾滋病毒传播(覆盖。在密集的性派对网络中HIV阴性的GBM可能会将PrEP添加到他们的药物方案中，以积极减少化疗期间艾滋病毒传播的可能性。目的：我们描述了同时使用甲基苯丙胺、Truvade(TM)(或其仿制药)、Viagra(TM)或其他勃起功能障碍药物(统称为MTV)的流行率和背景。方法：以下生活经历变化研究是对澳大利亚GBM合法和非法药物使用的在线前瞻性观察研究。在2017年1月至7月期间，1831个GBM提供了他们使用MTV的详细情况。结果：6.0%的受试者同时使用MTV；3.1%的受试者同时使用甲基苯丙胺和伟哥(TM)或其他勃起功能障碍药物(仅限MV)；11.2%的受试者仅使用Truvade作为PrEP。在多因素分析中，与单纯使用MV相比，在过去6个月中，MTV与有临时伴侣(AOR=6.78；95%CI=1.42-32.34)和‘性交’(AOR=3.47；95%CI=1.41-8.56)的Clai独立相关。与单纯使用‘T’相比，MTV与年龄(AOR=3.95；95%CI=1.55-10.03)和参与群体性行为(AOR=3.31；95%CI=1.82-6.00)独立相关。与仅使用MV或仅使用T相比，与其他男同性恋者更多的社交接触(AOR=1.44；95%CI=1.18-1.76)和有更多的性伴侣(AOR=2.30；95%CI=1.10-4.82)是使用MTV的独立相关因素。结论：在密集的性派对网络中，GBM越来越多地使用PrEP和其他药物来增强性体验。在化学性行为中推广使用PrEP的干预措施可以降低艾滋病毒风险。
Introduction: Gay and bisexual men (GBM) often use illicit drugs to enhance sexual pleasure, commonly referred to as 'chemsex' or 'party n play'. In particular, the use of methamphetamine and Viagra (TM), and other erectile dysfunction medications, both together and separately are strongly predictive of subsequent HIV infection. Truvada (TM), as pre-exposure prophylaxis (PrEP), virtually eliminates HIV transmission during condomless anal intercourse (CLAD. HIV-negative GBM in intensive sex partying networks may be adding PrEP to their drug regimen to actively reduce the possibility of HIV transmission during chemsex.Aim: We describe the prevalence and context of concurrent use of methamphetamine, Truvade (TM) (or its generic formulations), and Viagra (TM) or other erectile dysfunction medication (collectively, MTV).Method: The Following Lives Undergoing Change study is an online prospective observational study of licit and illicit drug use among Australian GBM. Between January and July 2017, 1831 GBM provided details about their use of MTV. Binary logistic multiple regression analysis were used to estimate adjusted odds ratios (aOR) and associated 95% confidence intervals (95%CI).Results: Concurrent MTV use was reported by 6.0% of participants; 3.1% used methamphetamine and Viagra (TM) or other erectile dysfunction medication ('MV only') and 11.2% used Truvade as PrEP only'). In multivariate analysis, compared to use of 'MV only', MTV was independently associated with CLAI with casual partners (aOR = 6.78;95%CI = 1.42-32.34) and 'fuckbuddies' (aOR = 3.47;95%CI = 1.41-8.56) in the previous six months. Compared to use of 'T only', MTV was independently associated with being older (aOR = 3.95;95%CI = 1.55-10.03) and engaging in group sex (aOR = 3.31;95%CI = 1.82-6.00). Greater social engagement with other gay men (aOR = 1.44;95%CI = 1.18-1.76) and having more sexual partners (aOR = 2.30;95%CI = 1.10-4.82) were independently associated with use of MTV compared to use of 'MV only' or 'T only'.Conclusion: GBM in intensive sex partying networks are increasingly adding PrEP alongside other drugs they use to enhance sexual experiences. Interventions that promote the use of PrEP during chemsex could mitigate HIV risk.