Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smoke
Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smoke
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DOI：
10.1136/tobaccocontrol-2018-054325
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发表时间：
2018-11-01
期刊：
影响因子：
5.2
通讯作者：
Springer, Matthew L.
中科院分区：
文献类型：
--
作者：
Nabavizadeh, Pooneh;Liu, Jiangtao;Springer, Matthew L.
背景加热烟草产品（也称为“加热不燃烧”产品）在低于燃烧温度的温度下加热烟草，导致尼古丁和其他化合物雾化。其中一种产品，菲利普莫里斯国际公司的IQOS，正在国际上销售，声称可以减少伤害。我们试图确定暴露于IQOS气雾剂是否会损害动脉血流介导的扩张（FMD），这是一种测量烟草烟雾损害的血管内皮功能的方法。（n=8/组）通过鼻锥至来自单个HeatStick的IQOS气雾剂，从单一的万宝路红色香烟或清洁空气的主流烟雾为一系列连续30秒的周期超过1.5-每个循环包括15或5秒的暴露，然后从鼻锥中取出。我们测量了暴露前和暴露后的FMD，和暴露后的血清尼古丁和可替nine.Results受损FMD由10个15 s和10个5 s暴露于IQOS气溶胶和香烟烟雾，但不是由清洁的空气。血清尼古丁水平与人类吸一支烟后的血浆水平相似，证实了暴露条件具有现实意义。暴露于IQOS的大鼠中暴露后尼古丁水平相似，是暴露于香烟的4.5倍，尽管在IQOS气雾剂中测得的尼古丁含量相似于烟雾中测得的尼古丁含量的63%。当IQOS暴露是briefer，导致可比的血清尼古丁水平的香烟组，FMD仍然是不可逆的imported.Conclusions急性暴露于IQOS气溶胶损害FMD大鼠。使用IQOS并不一定能避免吸烟对心血管的不良影响。
Background Heated tobacco products (also called 'heat-not-burn' products) heat tobacco at temperatures below that of combustion, causing nicotine and other compounds to aerosolise. One such product, IQOS from Philip Morris International, is being marketed internationally with claims of harm reduction. We sought to determine whether exposure to IQOS aerosol impairs arterial flow-mediated dilation (FMD), a measure of vascular endothelial function that is impaired by tobacco smoke.Methods We exposed anaesthetised rats (n=8/group) via nose cone to IQOS aerosol from single HeatSticks, mainstream smoke from single Marlboro Red cigarettes or clean air for a series of consecutive 30 s cycles over 1.5-5 min. Each cycle consisted of 15 or 5 s of exposure followed by removal from the nose cone. We measured pre-exposure and postexposure FMD, and postexposure serum nicotine and cotinine.Results FMD was impaired comparably by ten 15 s exposures and ten 5 s exposures to IQOS aerosol and to cigarette smoke, but not by clean air. Serum nicotine levels were similar to plasma levels after humans have smoked one cigarette, confirming that exposure conditions had real-world relevance. Postexposure nicotine levels were similar to 4.5-fold higher in rats exposed to IQOS than to cigarettes, despite nicotine being measured in the IQOS aerosol at similar to 63% the amount measured in smoke. When IQOS exposure was briefer, leading to comparable serum nicotine levels to the cigarette group, FMD was still comparably impaired.Conclusions Acute exposures to IQOS aerosol impairs FMD in rats. IQOS use does not necessarily avoid the adverse cardiovascular effects of smoking cigarettes.