Science Signaling Podcast for 24 January 2017: Tissue-specific regulation of L-type calcium channels.
Science Signaling Podcast for 24 January 2017: Tissue-specific regulation of L-type calcium channels.
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2017 年 1 月 24 日科学信号播客：L 型钙通道的组织特异性调节。
DOI：
10.1126/scisignal.aam6582
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发表时间：
2017
影响因子：
7.3
通讯作者：
VanHook,AnnalisaM
中科院分区：
文献类型：
--
作者：
Hell,JohannesW;Navedo,ManuelF;VanHook,AnnalisaM
This Podcast features an interview with Johannes Hell and Manuel Navedo, senior authors of two Research Articles that appear in the 24 January 2017 issue ofScience Signaling, about tissue-specific regulation of the L-type calcium channel CaV1.2. This channel is present in many tissues, including the heart, vasculature, and brain, and allows calcium to flow into cells when it is activated. Signaling through the β-adrenergic receptor (βAR) stimulates CaV1.2 activity in heart cells and neurons to accelerate heart rate and increase neuronal excitability, respectively. Using mouse models, Qianet al. found that βAR-mediated enhancement of CaV1.2 activity in the brain required phosphorylation of Ser1928, whereas βAR-mediated enhancement of CaV1.2 activity in the heart did not require phosphorylation of this residue. In a related study, Nystoriaket al. demonstrated that phosphorylation of Ser1928in arterial myocytes was required for vasoconstriction during acute hyperglycemia and in diabetic mice. These findings demonstrate tissue-specific differences in CaV1.2 regulation and suggest that it may be possible to design therapies to target this channel in specific tissues.Listen to Podcast
