The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice.
The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice.
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DOI：
10.1038/s41598-021-02550-2
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发表时间：
2021-11-29
影响因子：
4.6
通讯作者：
Panguluri SK
中科院分区：
文献类型：
--
作者：
Bojkovic K;Rodgers JL;Vichare R;Nandi A;Mansour H;Saleem F;Abidin ZU;Vanthenapalli S;Cheng F;Panguluri SK
补充氧气虽然是急诊和心血管医学的基石，但往往导致高氧，这是一种以组织氧过量为特征的疾病，导致不利的心脏重塑和随后对生理功能的有害影响。心脏重塑进一步受到各种危险因素的影响，包括先前存在的疾病和性别。因此，本实验的目的是研究高氧处理下I型糖尿病（秋田）小鼠的心脏重塑。总的来说，我们证明了秋田小鼠与野生型（WT）小鼠经历了不同的挑战。具体而言，与WT对照组相比，在常氧和高氧条件下，秋田雄性小鼠的体重和心脏重量均显著降低，PR、QRS和QTc间隔延长，常氧条件下EF %和FS %均降低。此外，就所研究的参数而言，秋田雄性小鼠与雌性小鼠（包括WT和秋田）在很大程度上相似。最后，统计分析显示，高氧对心脏病理生理的影响最大，其次是性别，最后是基因型。综上所述，我们的数据表明，与非并发症患者相比，I型糖尿病患者在高氧条件下可能具有不同的心脏病理生理，其中男性风险较高。这些发现可用于加强I型糖尿病合并症ICU患者的护理。
Oxygen supplementation, although a cornerstone of emergency and cardiovascular medicine, often results in hyperoxia, a condition characterized by excessive tissue oxygen which results in adverse cardiac remodeling and subsequent injurious effects to physiological function. Cardiac remodeling is further influenced by various risk factors, including pre-existing conditions and sex. Thus, the purpose of this experiment was to investigate cardiac remodeling in Type I Diabetic (Akita) mice subjected to hyperoxic treatment. Overall, we demonstrated that Akita mice experience distinct challenges from wild type (WT) mice. Specifically, Akita males at both normoxia and hyperoxia showed significant decreases in body and heart weights, prolonged PR, QRS, and QTc intervals, and reduced %EF and %FS at normoxia compared to WT controls. Moreover, Akita males largely resemble female mice (both WT and Akita) with regards to the parameters studied. Finally, statistical analysis revealed hyperoxia to have the greatest influence on cardiac pathophysiology, followed by sex, and finally genotype. Taken together, our data suggest that Type I diabetic patients may have distinct cardiac pathophysiology under hyperoxia compared to uncomplicated patients, with males being at high risk. These findings can be used to enhance provision of care in ICU patients with Type I diabetes as a comorbid condition.
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DOI：
10.1056/nejmoa1000485
发表时间：
2010-07-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Basaria S;Coviello AD;Travison TG;Storer TW;Farwell WR;Jette AM;Eder R;Tennstedt S;Ulloor J;Zhang A;Choong K;Lakshman KM;Mazer NA;Miciek R;Krasnoff J;Elmi A;Knapp PE;Brooks B;Appleman E;Aggarwal S;Bhasin G;Hede-Brierley L;Bhatia A;Collins L;LeBrasseur N;Fiore LD;Bhasin S
通讯作者：
Bhasin S
影响因子：
8.8
作者：
Janz DR;Hollenbeck RD;Pollock JS;McPherson JA;Rice TW
通讯作者：
Rice TW
DOI：
10.1183/20734735.000318
发表时间：
2018-06
期刊：
Breathe (Sheffield, England)
影响因子：
--
作者：
LoMauro A;Aliverti A
通讯作者：
Aliverti A
影响因子：
15.1
作者：
Page, David;Ablordeppey, Enyo;Fuller, Brian M.
通讯作者：
Fuller, Brian M.
DOI：
10.1152/ajplung.00304.2020
发表时间：
2021-01-01
影响因子：
4.9
作者：
Hanidziar, Dusan;Robson, Simon C.
通讯作者：
Robson, Simon C.