UNCOVERING THE MOLECULAR BASIS OF POSITIVE AFFECT USING ROUGH-AND-TUMBLE PLAY IN RATS: A ROLE FOR INSULIN-LIKE GROWTH FACTOR I
UNCOVERING THE MOLECULAR BASIS OF POSITIVE AFFECT USING ROUGH-AND-TUMBLE PLAY IN RATS: A ROLE FOR INSULIN-LIKE GROWTH FACTOR I
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DOI：
10.1016/j.neuroscience.2010.03.045
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发表时间：
2010-07-14
期刊：
影响因子：
3.3
通讯作者：
Moskal, J. R.
中科院分区：
文献类型：
--
作者：
Burgdorf, J.;Kroes, R. A.;Moskal, J. R.
在人类中，积极的情绪状态已被证明能够增强对抑郁和焦虑的抵抗力，但这些效应背后的分子机制尚未被阐明。在实验室大鼠中，积极的情绪状态可以通过50 khz的超声波发声(享乐USV)来测量，这是由青少年打闹游戏行为最大限度地引发的。利用聚焦的微阵列平台，胰岛素样生长因子I(IGFI)细胞外信号基因被发现在享乐性的混乱游戏中上调，但不会导致抑郁的社会失败。侧脑室注射IGFI以IGFI受体(IGFIR)依赖的方式增加享乐性USV的发生率。侧脑室注入IGFIR特异的siRNA可降低享乐性50 kHzUSV的发生率。这些结果表明IGFI在积极情绪状态的产生中起作用，IGFI依赖的信号转导是治疗抑郁和焦虑的潜在靶点。(C)2010年IBRO。爱思唯尔有限公司出版。保留所有权利。
Positive emotional states have been shown to confer resilience to depression and anxiety in humans, but the molecular mechanisms underlying these effects have not yet been elucidated. In laboratory rats, positive emotional states can be measured by 50-kHz ultrasonic vocalizations (hedonic USVs), which are maximally elicited by juvenile rough-and-tumble play behavior. Using a focused microarray platform, insulin-like growth factor I (IGFI) extracellular signaling genes were found to be upregulated by hedonic rough-and-tumble play but not depressogenic social defeat. Administration of IGFI into the lateral ventricle increased rates of hedonic USVs in an IGFI receptor (IGFIR)-dependent manner. Lateral ventricle infusions of an siRNA specific to the IGFIR decreased rates of hedonic 50-kHz USVs. These results show that IGFI plays a functional role in the generation of positive affective states and that IGFI-dependent signaling is a potential therapeutic target for the treatment of depression and anxiety. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.