Biology of CD34+CD38- cells in lymphohematopoiesis
Biology of CD34+CD38- cells in lymphohematopoiesis
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DOI：
10.3109/10428199809059221
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发表时间：
1998-10-01
影响因子：
2.6
通讯作者：
Civin, CI
中科院分区：
文献类型：
--
作者：
Novelli, EM;Ramirez, M;Civin, CI
自CD 34干/祖细胞抗原发现以来，在进一步纯化人淋巴造血干细胞（HSC）方面取得了相当大的进展。这些研究已经鉴定了许多可以靶向亚fractionate CD 34（+）细胞群的抗原。特别是，一些证据表明，罕见的CD 34（+）细胞的CD 38（-）亚群可能在HSC中富集。本文简要介绍了CD 38分子的相关知识以及CD 34（+）38（-）细胞的体内外研究结果。纯化的CD 34 +38-细胞的可能的临床用途进行了概述。
Since the discovery of the CD34 stem/progenitor cell antigen, considerable progress has been made in further purifying human lymphohematopoietic stem cells (HSC). These studies have identified a number of antigens which can be targeted to subfractionate the CD34(+) cell population. In particular, several lines of evidence suggest that the rare CD38(-) subpopulation of CD34(+) cells may be enriched in HSC. This review briefly summarizes relevant knowledge concerning the CD38 molecule and the results of in vitro and in vivo studies of CD34(+)38(-) cells. Possible clinical uses for purified CD34+38- cells are outlined.