Reduction-responsive PEtOz-SS-PCL micelle with tailored size to overcome blood-brain barrier and enhance doxorubicin antiglioma effect.
Reduction-responsive PEtOz-SS-PCL micelle with tailored size to overcome blood-brain barrier and enhance doxorubicin antiglioma effect.
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具有定制尺寸的还原响应性 PEtOz-SS-PCL 胶束可克服血脑屏障并增强阿霉素抗神经胶质瘤效果
DOI：
10.1080/10717544.2017.1402218
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发表时间：
2017-11
期刊：
影响因子：
6
通讯作者：
Hongmei L
中科院分区：
文献类型：
--
作者：
Li Y;Baiyang L;Leran B;Zhen W;Yandong X;Baixiang D;Dandan Z;Yufu Z;Jun L;Rutong Y;Hongmei L
以两亲性嵌段共聚物聚（2-乙基-2-恶唑啉）-b-聚（ε-己内酯）（PEtOz-SS-PCL）为基础，通过设计聚合物结构，制备了一系列可调控胶束尺寸的新型还原响应性胶束，用于释放阿霉素（DOX）治疗脑胶质瘤。负载DOX的PEtOz-SS-PCL胶束尺寸小，在还原性细胞内环境中药物释放迅速。在C6胶质瘤小鼠肿瘤模型中的生物分布和体内成像研究表明，具有最小尺寸的DOX负载的PEtOz-SS-PCL 43胶束在肿瘤部位具有上级蓄积和快速释药。体内抗肿瘤活性表明，与具有较大尺寸的PEtOz-SS-PCL胶束相比，DOX负载的PEtOz-SS-PCL 43胶束改善了对原位C6-Luci细胞荷瘤小鼠的抗肿瘤功效。这项研究显示了巨大的潜力，在定制胶束的大小和引入响应键或隔室的细胞内药物输送和释放在胶质瘤治疗通过设计的聚合物的架构。
A series of novel reduction-responsive micelles with tailored size were designed and prepared to release doxorubicin (DOX) for treating glioma, which were developed based on amphiphilic block copolymer poly (2-ethyl-2-oxazoline)-b-poly (ε-caprolactone) (PEtOz-SS-PCL) and the micelle size could be regulated by designing the polymer structure. The DOX-loaded PEtOz-SS-PCL micelles had small size and rapid drug release in reductive intracellular environments. Biodistribution and in vivo imaging studies in C6 glioma mice tumor model showed that DOX loaded PEtOz-SS-PCL43 micelles with the smallest size had superior accumulation and fast drug release in tumor sites. In vivo antitumor activity demonstrated that DOX-loaded PEtOz-SS-PCL43 micelles improved antitumor efficacy in contrast to PEtOz-SS-PCL micelles with larger size toward the orthotopic C6-Luci cells-bearing mice. This study shows great potential in tailoring the micelle size and introducing the responsive bonds or compartment for intracellular drug delivery and release in glioma treatment by designing the architecture of the polymer.
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影响因子：
3.9
作者：
Minniti, G.;De Sanctis, V.;Enrici, R. Maurizi
通讯作者：
Enrici, R. Maurizi
影响因子：
14
作者：
Liu R;Colby AH;Gilmore D;Schulz M;Zeng J;Padera RF;Shirihai O;Grinstaff MW;Colson YL
通讯作者：
Colson YL
由两亲性阿霉素-人血清白蛋白缀合物自组装的氧化还原敏感胶束状纳米粒子，用于肿瘤靶向治疗
影响因子：
--
作者：
Chen L;Chen F;Zhao M;Zhu X;Ke C;Yu J;Yan Z;Zhang F;Sun Y;Chen D;Jiang C;Zhao X;Gao Y;Guo S;Li W
通讯作者：
Li W
影响因子：
10.8
作者：
Kunjachan S;Detappe A;Kumar R;Ireland T;Cameron L;Biancur DE;Motto-Ros V;Sancey L;Sridhar S;Makrigiorgos GM;Berbeco RI
通讯作者：
Berbeco RI
DOI：
10.1039/c6tb03038f
发表时间：
2017-03-21
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
Senevirathne SA;Washington KE;Miller JB;Biewer MC;Oupicky D;Siegwart DJ;Stefan MC
通讯作者：
Stefan MC