Molecular biology of hair morphogenesis: development and cycling.
Molecular biology of hair morphogenesis: development and cycling.
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DOI：
10.1002/jez.b.33
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发表时间：
2003-08
期刊：
影响因子：
--
通讯作者：
V. Botchkarev;R. Paus
中科院分区：
文献类型：
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作者：
V. Botchkarev;R. Paus
在哺乳动物中，毛囊产生的毛发具有多种功能，包括体温调节、收集感觉信息、防止环境创伤、社交交流和模仿。毛囊的发育是负责毛发特异性分化的表皮角质形成细胞与形成毛囊乳头的真皮成纤维细胞簇之间上皮间质相互作用的结果。在出生后的生活中，毛囊表现出周期性活动模式，包括活跃生长和毛发生成（毛发生长初期）、细胞凋亡驱动的退化（毛发生长中期）和相对静止（毛发生长终期）时期。在过去的十年中，在描述控制毛囊发育和循环活动的分子机制方面取得了实质性进展。在这篇综述中，我们总结了数据，证明胚胎中毛囊发育的调节和出生后毛囊生长的控制是高度保守的，并且都需要类似的分子机制的参与。由于许多控制毛囊发育和循环的分子也参与调节其他外胚层衍生物（例如牙齿、羽毛和乳腺）的形态发生和产后生物学，因此控制毛囊发育和生长的基本原理和分子机制也可能适用于其他发育系统。
In mammals, hair follicles produce hairs that fulfill a number of functions including thermoregulation, collecting sensory information, protection against environmental trauma, social communication, and mimicry. Hair follicles develop as a result of epithelial-mesenchymal interactions between epidermal keratinocytes committed to hair-specific differentiation and cluster of dermal fibroblasts that form follicular papilla. During postnatal life, hair follicles show patterns of cyclic activity with periods of active growth and hair production (anagen), apoptosis-driven involution (catagen), and relative resting (telogen). During last decade, substantial progress has been achieved in delineating molecular mechanisms that control hair follicle development and cyclic activity. In this review, we summarize the data demonstrating that regulation of hair follicle development in the embryo and control of hair follicle growth during postnatal life are highly conserved and both require involvement of similar molecular mechanisms. Since many of the molecules that control hair follicle development and cycling are also involved in regulating morphogenesis and postnatal biology of other ectodermal derivatives, such as teeth, feathers, and mammary glands, basic principles and molecular mechanisms that govern hair follicle development and growth may also be applicable for other developmental systems.