Effect of network connectivity on the mechanical and transport properties of block copolymer gels
Effect of network connectivity on the mechanical and transport properties of block copolymer gels
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DOI：
10.1002/pol.20200695
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发表时间：
2020-11-20
影响因子：
3.4
通讯作者：
Mineart, Kenneth P.
中科院分区：
文献类型：
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作者：
Rankin, Lucas A.;Lee, Byeongdu;Mineart, Kenneth P.
在聚合物凝胶中建立传输和机械性能的独立可调性将极大地促进其作为经皮给药介质的实施。在此进行的工作使用物理交联型苯乙烯基ABA/AB嵌段共聚有机凝胶配方中的简单改变来改变其机械性能，而不依赖于内部负载的纳米载体的质量传输。这种独立的可调性是通过改变ABA三嵌段和AB两嵌段共聚物的相对含量而实现的，同时保持共聚物的总浓度不变。具体地说，研究了三个系列的凝胶，每个凝胶具有固定的总共聚物浓度(10、20或30wt%)，其中包括不同的三嵌段共聚物浓度。小角x射线散射证实，在纳米尺度上，每个系列只改变凝胶网络的连接性，而力学和释放实验表明，网络连接性的增加导致凝胶模数显著增加，但纳米载体的释放速率变化不大。
Establishing the independent tunability of transport and mechanical properties in polymer gels would significantly contribute to their implementation as transdermal drug delivery media, among other things. The work conducted herein uses facile changes in the formulation of physically crosslinked styrenic ABA/AB block copolymer organogels to alter their mechanical properties independently from the mass transport of an internally-loaded nanocarrier. Such independent tunability is made possible by altering the relative amounts of ABA triblock and AB diblock copolymers while holding total copolymer concentration fixed. Specifically, three series of gels each with a fixed total copolymer concentration (10, 20, or 30 wt%) comprised of varying triblock copolymer concentration are studied. Small angle x-ray scattering confirms that, at the nanoscale, only gel network connectivity changes within each series, while mechanical and release experiments show that increasing network connectivity leads to significant growth of gel moduli, but little change in nanocarrier release rate.