Smoking and liver cancer in China: Case-control comparison of 36,000 liver cancer deaths vs. 17,000 cirrhosis deaths
Smoking and liver cancer in China: Case-control comparison of 36,000 liver cancer deaths vs. 17,000 cirrhosis deaths
复制标题
DOI：
10.1002/ijc.11342
复制
发表时间：
2003-10-20
影响因子：
6.4
通讯作者：
Peto, R
中科院分区：
文献类型：
--
作者：
Chen, ZM;Liu, BQ;Peto, R
肝癌和肝硬化是中国常见的死亡原因，慢性终身B型肝炎感染是这两种疾病的主要原因。为了帮助确定吸烟是否是肝癌发展的辅助因素，我们回顾性地确定了中国24个城市和74个农村县的36，000名死于肝癌（病例）和17，000名死于肝硬化（对照）的成年人的吸烟习惯。吸烟者与非吸烟者肝癌死亡率风险比（RR）的计算按年龄和地区标准化。在成年男性（35岁以上）中，吸烟者死于肝癌的风险高出36%（吸烟者与非吸烟者的标准化风险比[RR] = 1.36，95%置信区间[CI] 1.29-1.43，2 p
Liver cancer and liver cirrhosis are common causes of death in China, where chronic lifelong hepatitis B infection is a major cause of both diseases. To help determine whether smoking is a cofactor for the development of liver cancer, we ascertained retrospectively the smoking habits of 36,000 adults who had died from liver cancer (cases) and 17,000 who had died from cirrhosis (controls) in 24 Chinese cities and 74 rural counties. Calculations of the smoker vs. nonsmoker risk ratios (RR) for liver cancer mortality were standardised for age and locality. Among adult men (aged 35+) there was a 36% excess risk of death from liver cancer among smokers (smoker vs. nonsmoker standardised risk ratio [RR] = 1.36, with 95% confidence interval [CI] 1.29-1.43, 2p