Sun exposure and non-Hodgkin lymphoma: A population-based, case-control study
Sun exposure and non-Hodgkin lymphoma: A population-based, case-control study
复制标题
DOI：
10.1016/j.ejca.2007.06.018
复制
发表时间：
2007-11-01
影响因子：
8.4
通讯作者：
Chiu, Brian C. -H.
中科院分区：
文献类型：
--
作者：
Soni, Lori K.;Hou, Lifang;Chiu, Brian C. -H.
为了研究阳光照射与非霍奇金淋巴瘤（NHL）组织学亚型风险之间的关系，并探讨维生素D摄入是否改变阳光与NHL的关系，我们分析了1999年至2002年在内布拉斯加州进行的一项基于人群的病例对照研究的数据。采用电话访谈的方法收集了387例病例和535例对照者春、夏、秋、冬四季的日照情况。我们发现季节性阳光照射与NHL风险之间没有关联。维生素D的摄入也与NHL风险无关，也不改变阳光与NHL的关联.相比之下，总日照时间与NHL风险呈负相关（比值比（OR）= 0.7，比较> 30小时/周与< 14小时/周，95%置信区间（CI）= 0.5 - 1.1）。在农民中，阳光照射与NHL的低风险相关（14 - 30小时/周的OR = 0.8，0.5 - 1.3;> 30小时/周的OR = 0.6，0.3 - 0.9; p趋势= 0.02），但在非农民中则不然。总日照时间也与弥漫性大B细胞淋巴瘤和T细胞淋巴瘤的风险呈负相关。总之，我们的数据表明，总日照时间与NHL的风险较低相关，并且这种负相关性不受维生素D摄入量的影响，在农民中更强，并且可能因亚型而异。(c)2007爱思唯尔有限公司保留所有权利。
To investigate the association between sun exposure and risk of non-Hodgkin lymphoma (NHL) by histologic subtypes and to explore whether or not vitamin D intake modify sun - NHL association, we analysed data from a population-based, case - control study conducted in Nebraska between 1999 and 2002. Information on sun exposure during the spring, summer, fall and winter was collected from 387 cases and 535 controls by telephone interview. We found no association between seasonal sun exposure and risk of NHL. Vitamin D intake was also not associated with NHL risk, nor does it modify the sun - NHL association. In contrast, total hours of sun exposure was inversely associated with the risk of NHL (odds ratio (OR) = 0.7 comparing > 30 h/week to < 14 h/week, 95% confidence interval (CI) = 0.5 - 1.1). Sun exposure was associated with a lower risk of NHL among farmers (OR = 0.8, 0.5 - 1.3 for 14 - 30 h/week; OR = 0.6, 0.3 - 0.9 for > 30 h/week; p-trend = 0.02), but not among non-farmers. Total hours of sun exposure was also inversely associated with risk of diffuse large B-cell lymphoma and T-cell lymphoma. In conclusion, our data suggest that total hours of sun exposure is associated with a lower risk of NHL, and the inverse association is not modified by vitamin D intake, is stronger among farmer, and may vary by subtypes. (c) 2007 Elsevier Ltd. All rights reserved.