Acute effects of a high-fat diet on estrous cycling and body weight of intact female mice.
Acute effects of a high-fat diet on estrous cycling and body weight of intact female mice.
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高脂肪饮食对未绝育雌性小鼠的发情周期和体重的急性影响。
DOI：
10.1038/s41386-021-01164-6
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Burton,MichaelD
中科院分区：
文献类型：
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作者：
Lenert,MelissaE;Burton,MichaelD
由于生殖障碍的发病发生在年轻患者中，与西方饮食（高脂肪和糖）和青少年肥胖的相关性使我们关注这些因素对生殖健康的影响。早期生殖系统疾病，如青少年多囊卵巢综合征，表现为胰岛素抵抗、甘油三酯升高和卵巢功能障碍[1]。因此，了解调节全身代谢的机制是减轻生殖障碍症状的一个重要方面[2]。历史上，雌性小鼠不用于生殖和代谢研究，因为它们不能表现出与肥胖一致的长期代谢异常[3]。最近的证据表明，卵巢激素在这一现象中起着重要作用，因为在高脂肪饮食（HFD;> 40%千卡来自脂肪）之前切除卵巢会导致与男性相似的体重增加率。评估HFD小鼠性激素水平的研究随后进行（12周+），但没有检查西方药物的急性作用。
As the onset of reproductive disorders occur in younger patients, correlations to the western diet (high in fats and sugars) and adolescent obesity leads us to focus on these factorsL effects on reproductive health. Early reproductive disorders such as adolescent polycystic ovarian syndrome present with insulin resistance, elevated triglycerides, and ovarian dysfunction [1]. Thus, understanding the mechanisms that regulate whole-body metabolism is an important aspect of mitigating symptoms of reproductive disorders [2].Historically, female mice were not used in reproductive and metabolic studies because they fail to present the long-term metabolic abnormalities consistent with obesity [3]. Recent evidence has shown that ovarian hormones play an important role in this phenomenon, as removal of the ovaries prior to a high-fat diet (HFD;> 40% kcal from fats) results in similar rates of weight gain as in males. Studies that assess sex hormone levels in mice on HFD follow them (12 weeks+) and have not examined acute effects of western