Association between nocturnal vagal tone and sleep depth, sleep quality, and fatigue in alcohol dependence
Association between nocturnal vagal tone and sleep depth, sleep quality, and fatigue in alcohol dependence
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DOI：
10.1097/01.psy.0000195743.60952.00
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发表时间：
2006-01-01
影响因子：
3.3
通讯作者：
Ehlers, CL
中科院分区：
文献类型：
--
作者：
Irwin, MR;Valladares, EM;Ehlers, CL
背景资料：本研究探讨了夜间迷走神经张力是否与心率变异性的高频（HF）功率分量指数相关的睡眠深度和白天的睡眠质量，嗜睡和疲劳的酒精依赖性的看法的措施。研究方法：戒酒酒精依赖患者（n = 14）和对照组受试者（17 = 14）进行了整夜多导睡眠图沿着睡眠前清醒期和睡眠期间的心率变异性评估。睡眠质量的感知，沿着自我报告的困倦程度和精力与疲劳程度，在早晨获得。结果如下：与对照受试者相比，酒精依赖者的δ睡眠沿着显著减少，睡眠质量和白天精力受损。此外，与对照组相比，酗酒者在睡眠前的清醒期和夜间睡眠期间心率变异性的HF功率分量减少。HF功率在清醒期间在睡眠前与脑电图δ睡眠和δ功率在随后的睡眠期间观察到。睡眠前清醒期的高频功率也与早晨的睡眠质量、嗜睡和疲劳报告相关。结论：酒精依赖损害了在入睡前测量的迷走神经输出，这与δ睡眠的丧失和早晨睡眠障碍的报告有关。针对交感迷走神经平衡的干预措施的测试可能会发现新的策略，部分改善睡眠障碍和白天功能障碍的人与酒精依赖。
Background: This study examined whether nocturnal vagal tone as indexed by the high-frequency (HF) power component of heart rate variability is related to measures of sleep depth and daytime perceptions of sleep quality, sleepiness, and fatigue in alcohol dependence. Methods: Abstinent alcohol-dependent patients (n = 14) and comparison control Subjects (17 = 14) underwent all-night polysomnography along with assessment of heart rate variability during an awake period before sleep and during sleep. Sleep-quality perceptions, along with self-reported sleepiness and levels of energy and fatigue, were obtained in the morning. Results: As compared with control Subjects, alcohol-dependent persons showed marked decreases in delta sleep along with impairments of sleep quality and daytime energy. In addition, alcoholics showed a decrease of the HF power component of heart rate variability during the awake period before sleep and during nocturnal sleep as compared with control subjects. HF power during the awake period before sleep correlated with electroencephalographic delta sleep and delta power observed during the subsequent sleep period. HF power during the awake period before sleep also con-elated with morning reports of sleep quality, sleepiness, and fatigue. Conclusions: Alcohol dependence compromises vagal output measured before sleep onset, which correlates with loss of delta sleep and with morning reports of sleep impairments. Testing of interventions that target sympathovagal balance might identify new strategies for partial amelioration of the sleep disturbances and impairments in daytime functioning observed in persons with alcohol dependence.