Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease
Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2010.06.015
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发表时间：
2012-01-01
影响因子：
4.2
通讯作者：
Nordberg, Agneta
中科院分区：
文献类型：
--
作者：
Kadir, Ahmadul;Almkvist, Ove;Nordberg, Agneta
在这项研究中，5例轻度认知功能障碍（MCI）和9例阿尔茨海默病（AD）患者分别接受了3年和5年随访的N-甲基[（11）C] 2-（4-甲氨基苯基）-6-羟基-苯并噻唑（（11）C-PIB）和（18）F-氟脱氧葡萄糖（（18）F-FDG）的正电子发射断层扫描（PET）研究，以了解AD疾病过程的时间进程。在MCI患者组水平上观察到PIB潴留显著增加以及局部脑葡萄糖代谢率（rCMRglc）降低，而认知功能未观察到显著变化。在组水平上，与基线相比，AD患者在5年随访时显示出无变化的高PIB保留。在个体水平上，观察到PIB保留增加、稳定和减少，而疾病进展反映在rCMRglc和认知的显著降低中。总之，在PET长期随访后，我们观察到MCI患者的纤维淀粉样蛋白负荷增加，而临床AD患者的纤维淀粉样蛋白负荷水平更稳定。rCMRglc在MCI患者中开始下降，并在临床阶段变得更加明显，这与认知能力的持续下降有关。(C)2012 Elsevier Inc. All rights reserved.
In this study 5 patients with mild cognitive impairment (MCI) and 9 Alzheimer's disease (AD) patients underwent respectively 3- and 5-year follow-up positron emission tomography (PET) studies with N-methyl [(11)C] 2-(4-methylaminophenyl)-6-hydroxy-benzothiazole ((11)C-PIB) and (18)F-fluorodeoxyglucose ((18)F-FDG) to understand the time courses in AD disease processes. Significant increase in PIB retention as well as decrease in regional cerebral metabolic rate of glucose (rCMRglc) was observed at group level in the MCI patients while no significant change was observed in cognitive function. At group level the AD patients showed unchanged high PIB retention at 5-year follow-up compared with baseline. At the individual level, increased, stable, and decreased PIB retention were observed while disease progression was reflected in significant decrease in rCMRglc and cognition. In conclusion, after a long-term follow-up with PET, we observed an increase in fibrillar amyloid load in MCI patients followed by more stable level in clinical AD patients. The rCMRglc starts to decline in MCI patients and became more pronounced in clinical stage which related to continuous decline in cognition. (C) 2012 Elsevier Inc. All rights reserved.