Baseline leptin levels predict change in leptin levels during weight loss in obese breast cancer survivors.
Baseline leptin levels predict change in leptin levels during weight loss in obese breast cancer survivors.
复制标题
基线瘦素水平可预测肥胖乳腺癌幸存者减肥期间瘦素水平的变化。
DOI：
10.1111/j.1524-4741.2007.00397.x
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Djuric,Zora
中科院分区：
文献类型：
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作者：
Sen,Ananda;Jen,Kai-LinCatherine;Djuric,Zora
瘦素是一种脂肪细胞衍生的激素，参与调节饱腹感，它似乎也在乳腺癌风险中发挥作用。因此，瘦素可能是乳腺癌幸存者减肥潜在预防作用的有用指标。在这项研究中，我们研究了瘦素水平的变化是否可以通过肥胖乳腺癌幸存者的体重减轻来预测。本研究的受试者参加了在密歇根州底特律市进行的一项关于个体化减肥方法的随机试验。招募乳腺癌幸存者（体重指数为30-44 kg/m2），并在1年的研究中获得空腹血液样本用于瘦素分析。 36名女性的瘦素水平至少在两个时间点可用，体重变化范围从基线体重的11%增加到25%减少。使用重复测量回归模型，发现基线瘦素水平和并发体脂百分比两者协同预测瘦素水平。因此，对于具有相同体脂的女性，预测具有较高基线瘦素水平的那些女性随着体重减轻而表现出较小的瘦素下降。体重和体重变化也得到了类似的结果，但与体脂的关联更强。乳腺癌幸存者与最初较高的瘦素水平可能会有所不同，在减肥过程中的瘦素变化的调节，导致相对较小的变化瘦素与等量的体重减轻。
Leptin is an adipocyte‐derived hormone involved in regulation of satiety, and it also appears to have a role in breast cancer risk. Leptin therefore might be a useful indicator of the potential preventive effects of weight loss in breast cancer survivors. In this study we examined whether the change in leptin levels could be predicted by weight loss in obese breast cancer survivors. The subjects in this study were participating in a randomized trial of an individualized approach towards weight loss in Detroit, MI. Breast cancer survivors (body mass index of 30–44 kg/m2) were enrolled and fasting blood samples were obtained for leptin analysis over 1 year of study. Leptin levels were available from at least two time points for 36 women, and weight change ranged from a gain of 11% to a loss of 25% of baseline weight. Using a repeated‐measures regression model, both baseline leptin level and concurrent percent body fat were found to synergistically predict leptin levels. Thus, for women with the same body fat, those with higher baseline leptin levels are predicted to exhibit smaller decreases in leptin with weight loss. Similar results were obtained for body weight and body weight change, but the associations with body fat were stronger. Breast cancer survivors with initially higher leptin levels may differ with regard to regulation of change in leptin during weight loss resulting in relatively smaller changes in leptin with equivalent amounts of weight loss.