Microbial epitopes act as altered peptide ligands to prevent experimental autoimmune encephalomyelitis.
Microbial epitopes act as altered peptide ligands to prevent experimental autoimmune encephalomyelitis.
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DOI：
10.1084/jem.189.8.1275
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发表时间：
1999-04-19
期刊：
影响因子：
--
通讯作者：
Steinman L
中科院分区：
文献类型：
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作者：
Ruiz PJ;Garren H;Hirschberg DL;Langer-Gould AM;Levite M;Karpuj MV;Southwood S;Sette A;Conlon P;Steinman L
分子拟态是指自身蛋白质和微生物蛋白质之间的结构同源性。髓鞘碱性蛋白(MBP)的主要表位p87-99(VHFFKNIVTPRTP)可诱导实验性自身免疫性脑脊髓炎(EAE)。VHFFK含有这种自身分子与T细胞受体(TCR)和主要组织相容性复合体结合的主要残基。含有VHFFK基序的乳头瘤病毒株的多肽可诱导EAE。来自人类乳头瘤病毒40型(HPV40)的含有VHFFR的多肽和来自HPV32的含有VHFFH的多肽可以预防EAE。枯草芽孢杆菌(RKVTDFFKNIPQRI)的一个序列也可以预防EAE。T细胞系产生IL-4，并针对这些微生物多肽，抑制EAE。因此，微生物肽不同于自身抗原的核心基序MBPp87-99，在自身免疫性疾病的调节中，作为改变的多肽配体发挥作用，并作为TCR拮抗剂发挥作用。
Molecular mimicry refers to structural homologies between a self-protein and a microbial protein. A major epitope of myelin basic protein (MBP), p87–99 (VHFFKNIVTPRTP), induces experimental autoimmune encephalomyelitis (EAE). VHFFK contains the major residues for binding of this self-molecule to T cell receptor (TCR) and to the major histocompatibility complex. Peptides from papilloma virus strains containing the motif VHFFK induce EAE. A peptide from human papilloma virus type 40 (HPV 40) containing VHFFR, and one from HPV 32 containing VHFFH, prevented EAE. A sequence from Bacillus subtilis (RKVVTDFFKNIPQRI) also prevented EAE. T cell lines, producing IL-4 and specific for these microbial peptides, suppressed EAE. Thus, microbial peptides, differing from the core motif of the self-antigen, MBPp87–99, function as altered peptide ligands, and behave as TCR antagonists, in the modulation of autoimmune disease.