Supine plasma NE predicts the pressor response to droxidopa in neurogenic orthostatic hypotension
Supine plasma NE predicts the pressor response to droxidopa in neurogenic orthostatic hypotension
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DOI：
10.1212/wnl.0000000000006369
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发表时间：
2018-10-16
期刊：
影响因子：
9.9
通讯作者：
Kaufmann, Horatio
中科院分区：
文献类型：
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作者：
Palma, Jose-Alberto;Norcliffe-Kaufmann, Lucy;Kaufmann, Horatio
目的测试神经源性直立性低血压（nOH）患者血浆去甲肾上腺素（NE）水平是否可以预测其对屈昔多巴的升压反应。方法这是一项观察性研究，包括nOH患者。所有患者均接受标准化自主功能测试，包括测定仰卧休息时通过留置导管抽取的静脉血浆儿茶酚胺水平。随后连续几天以 100 mg 增量进行屈昔多巴滴定，直至症状、副作用缓解或达到 600 mg 的最大剂量。无反应被定义为增加
ObjectiveTo test whether the plasma levels of norepinephrine (NE) in patients with neurogenic orthostatic hypotension (nOH) predict their pressor response to droxidopa.MethodsThis was an observational study, which included patients with nOH. All patients had standardized autonomic function testing including determination of venous plasma catecholamine levels drawn through an indwelling catheter while resting supine. This was followed by a droxidopa titration with 100 mg increments in successive days until relief of symptoms, side effects, or the maximum dose of 600 mg was reached. No response was defined as an increase of