Encapsulation of Hydrophobic Drugs in Pluronic F127 Micelles: Effects of Drug Hydrophobicity, Solution Temperature, and pH
Encapsulation of Hydrophobic Drugs in Pluronic F127 Micelles: Effects of Drug Hydrophobicity, Solution Temperature, and pH
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DOI：
10.1021/la304836e
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发表时间：
2013-04-02
期刊：
影响因子：
3.9
通讯作者：
Bandyopadhyay, Ranjini
中科院分区：
文献类型：
--
作者：
Basak, Rajib;Bandyopadhyay, Ranjini
三种药物，布洛芬，阿司匹林和红霉素，封装在球形普朗尼克：F127胶束。的形状和大小分布的胶束在稀的水溶液中，有和没有药物，确定使用冷冻扫描电子显微镜和动态光散射（DLS）实验，分别。吸收的药物高于阈值浓度被认为是降低溶液的临界胶束化温度。胶束的平均流体动力学半径和多分散性被发现增加，在温度降低和药物分子的存在下。在较低的温度下的胶束核心的水合作用是使用荧光测量验证。增加溶液pH导致掺入胶束核中的药物的电离。这会导致胶束破裂，并在这里研究的最高溶液pH值11.36下将药物释放到溶液中，并使用DLS和荧光光谱进行研究。
Three drugs, ibuprofen, aspirin, and erythromycin, are encapsulated in spherical Pluronic: F127 micelles. The shapes and the size distributions of the micelles in dilute, aqueous solutions, with and without drugs, are ascertained using cryo-scanning electron microscopy and dynamic light: scattering (DLS) experiments, respectively. Uptake of drugs above a threshold concentration is seen to reduce the critical micellization temperature of the solution. The mean hydrodynamic radii and polydispersities of the micelles are found to increase with decrease in temperature and in the presence of drug molecules. The hydration of the micellar core at lower temperatures is verified using fluorescence measurements. Increasing solution pH leads to the ionization of the drugs incorporated in the micellar cores. This causes rupture of the micelles and release of the drugs into the solution at the highest solution pH value of 11.36 investigated here and is studied using DLS and fluorescence spectrocopy.