SUNSCREENS SUPPRESS CUTANEOUS VITAMIN-D3 SYNTHESIS
SUNSCREENS SUPPRESS CUTANEOUS VITAMIN-D3 SYNTHESIS
复制标题
DOI：
10.1210/jcem-64-6-1165
复制
发表时间：
1987-06-01
影响因子：
5.8
通讯作者：
HOLICK, MF
中科院分区：
文献类型：
--
作者：
MATSUOKA, LY;IDE, L;HOLICK, MF
防晒霜可以阻止皮肤吸收紫外线B辐射，防止晒伤、过早衰老和皮肤癌。由于UV-B辐射也负责维生素D3的光合作用，我们研究了防晒霜对体内和体外皮肤维生素D3形成的影响。8名正常受试者，其中4人已与防晒霜保护对氨基苯甲酸（防晒系数8），暴露于一个最小的红斑剂量的紫外线辐射。平均血清维生素D3浓度从1.5 . ±. 1.0 (.+-. SEM）至25.6 .+-。6.7 ng/mL，而在未受保护的受试者中为5.6 . ±. 3.0和4.4 .+-。2.4 ng/mL。对氨基苯甲酸也防止光异构化的7-脱氢胆固醇的前维生素D3在人体皮肤切片在体外。这些结果表明，防晒霜干扰了维生素D3的皮肤生产。
Sunscreens block the cutaneous absorption of UV-B radiation and prevent sunburning, premature aging, and cancer of the skin. Inasmuch as UV-B radiation is also responsible for the photosynthesis of vitamin D3, we investigated the effect of sunscreens on the cutaneous formation of vitamin D3 in vivo and in vitro. Eight normal subjects, four of whom had been protected with the sunscreen para-aminobenzoic acid (sun protection factor 8), were exposed to one minimal erythema dose of UV radiation. The mean serum vitamin D3 concentration increased from 1.5 .+-. 1.0 (.+-.SEM) to 25.6 .+-. 6.7 ng/mL in unprotected subjects, whereas it was 5.6 .+-. 3.0 and 4.4 .+-. 2.4 ng/mL at these times in the subjects who were protected with para-aminobenzoic acid. Para-aminobenzoic acid also prevented the photoisomerization of 7-dehydrocholesterol to previtamin D3 in human skin slices in vitro. These results indicate that the sunscreen interfered with the cutaneous production of vitamin D3.