The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins:: Novel oxygenase products from ω-3 polyunsaturated fatty acids
The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins:: Novel oxygenase products from ω-3 polyunsaturated fatty acids
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DOI：
10.1016/j.bbrc.2005.07.181
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发表时间：
2005-12-09
影响因子：
3.1
通讯作者：
Serhan, CN
中科院分区：
文献类型：
--
作者：
Arita, M;Clish, CB;Serhan, CN
消退素（Resolvins，Rvs）是衍生自ω-3多不饱和脂肪酸（PUFA）如二十碳五烯酸（EPA）和二十二碳六烯酸的含氧产物，其在消退炎性渗出物中具有有效的保护性生物作用。Resolvin E1（RvE 1）是在细胞-细胞相互作用期间通过跨细胞生物合成途径从EPA在体内生物合成的，因此RvE 1在多细胞反应（如炎症和微生物感染）期间在体内形成。RvE 1保护组织免受白细胞介导的损伤，并反调节促炎基因表达。这些新发现的Rvs可能是omega-3 PUFA的有益作用的基础，特别是在慢性疾病中，未解决的炎症是发病的关键机制。在这里，我们提出了RvE 1的生物合成的概述，重点是阿司匹林触发和微生物P450启动的途径。RvE 1的产生及其作用似乎可以抑制急性白细胞反应并促进炎症的消退。(c)2005年爱思唯尔公司All rights reserved.
Resolvins (Rvs) are oxygenated products derived from omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid that carry potent protective bioactions present in resolving inflammatory exudates. Resolvin E1 (RvE1) is biosynthesized in vivo from EPA via transcellular biosynthetic routes during cell-cell interactions, and thus RvE1 is formed in vivo during multicellular responses such as inflammation and microbial infections. RvE1 protects tissues from leukocyte-mediated injury and counterregulates proinflammatory gene expression. These newly identified Rvs may underlie the beneficial actions of omega-3 PUFAs especially in chronic disorders where unresolved inflammation is a key mechanism of pathogenesis. Here, we present an overview of the biosynthesis of RvE1, with a focus on the aspirin-triggered and microbial P450-initiated pathways. The generation of RvE1 and its actions appear to dampen acute leukocyte responses and facilitate the resolution of inflammation. (c) 2005 Elsevier Inc. All rights reserved.