Associations of plasma hypocretin-1 with metabolic and reproductive health: Two systematic reviews of clinical studies.
Associations of plasma hypocretin-1 with metabolic and reproductive health: Two systematic reviews of clinical studies.
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DOI：
10.1016/j.smrv.2020.101307
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发表时间：
2020-03
影响因子：
10.5
通讯作者：
G. Dunietz;G. Vanini;C. Shannon;L. O’Brien;R. Chervin
中科院分区：
文献类型：
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作者：
G. Dunietz;G. Vanini;C. Shannon;L. O’Brien;R. Chervin
竹红菌素系统由两个多肽组成：竹红素-1和竹红素-2(HCRT1和HCRT2)。下丘脑后部和外侧的下丘脑内含有下丘脑的神经元，在大脑和脊髓中有广泛的投射。除了在脑脊液(CSF)中存在外，外周血中也检测到了HCRT1。强有力的实验证据表明，下丘脑来源的HCRT1在调节与睡眠-觉醒状态、能量平衡和内分泌功能相关的多个生物系统中具有功能。相比之下，对人类参与者进行的HCRT1研究受限于对潜在疾病患者进行的脑脊液HCRT1的必要侵入性评估。HCRT1对动物体内能量平衡和生殖的调节表明，人类也有类似的调节，并促使这两项系统评价。这些综述将先前动物研究的实验结果转化为人类，并检查了HCRT1与以下因素之间的关联：1)代谢风险因素；2)男性、女性和儿童的生殖功能。共有21项研究和6项研究分别符合两次搜索的纳入标准。研究问题、研究设计、研究人群、HCRT1的评估、生殖、心脏代谢数据和主要发现被提炼出来。HCRT1、代谢和生殖功能之间的关联是不一致的。概述了研究的局限性和未来的研究方向。
The hypocretin system consists of two peptides hypocretin-1 and hypocretin-2 (HCRT1 and HCRT2). Hypocretin-containing neurons are located in the posterior and lateral hypothalamus, and have widespread projections throughout the brain and spinal cord. In addition to its presence in the cerebrospinal fluid (CSF), peripheral HCRT1 has been detected in plasma. Robust experimental evidence demonstrates functions of hypothalamic-originated HCRT1 in regulation of multiple biological systems related to sleep–wake states, energy homeostasis and endocrine function. In contrast, HCRT1 studies with human participants are limited by the necessarily invasive assessment of CSF HCRT1 to patients with underlying morbidity.Regulation by HCRT1 of energy homeostasis and reproduction in animals suggests similar regulation in humans and prompts these two systematic reviews. These reviews translate prior experimental findings from animal studies to humans and examine associations between HCRT1 and: 1) metabolic risk factors; 2) reproductive function in men, women and children. A total of 21 studies and six studies met the inclusion criteria for the two searches, respectively. Research question, study design, study population, assessments of HCRT1, reproductive, cardiometabolic data and main findings were extracted. Associations between HCRT1, metabolic and reproductive function are inconsistent. Limitations of studies and future research directions are outlined.