Adolescent obesity adversely affects blood pressure and resting heart rate
Adolescent obesity adversely affects blood pressure and resting heart rate
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DOI：
10.1253/circj.71.722
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发表时间：
2007-05-01
影响因子：
3.3
通讯作者：
Yokota, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Baba, Reizo;Koketsu, Masaaki;Yokota, Mitsuhiro
背景肥胖与高血压（HT）、高静息心率（HR）以及代谢紊乱有关。然而，鲜为人知的是如何强烈这些血流动力学异常与肥胖程度的adolescents.Methods和结果的身高，体重，静息心率，收缩压和舒张压进行了测量，在20,165名男性和19,683名女性高中生。根据体重指数将肥胖水平分为6组：第1组（<20百分位数）、第2组（20 - 39.9百分位数）、第3组（40 - 59.9百分位数）、第4组（60 - 79.9百分位数）、第5组（80 - 98.9百分位数）和第6组（>= 99百分位数）。收缩期和舒张期高血压分别定义为≥ 140 mmHg和≥ 85 mmHg。静息性心动过速定义为相应的第95百分位数或更高。男性和女性的静息心率、收缩压和舒张压均随肥胖水平的升高而升高（p < 0.0001）。收缩期HT和舒张期HT均与高静息HR相关，这些不利条件的聚集随着肥胖程度的增加而增加。结论血流动力学异常，如HT和高静息HR，与青少年肥胖密切相关，可能是由自主神经功能受损引起的。
Background Obesity is associated with hypertension (HT) and high resting, heart rate (HR), as well as metaC, bolic disturbances. However, little is known about how strongly these hemodynamic abnormalities are associated with the degree of obesity in adolescents.Methods and Results Height, body weight, resting HR, and systolic and diastolic blood pressures were measured in 20,165 male and 19,683 female high-school students. Adiposity levels were classified into 6 groups by body mass index: group 1 (< 20th percentile), group 2 (20th-39.9th percentile), group 3 (40th-59.9th percentile), group 4 (60th-79.9th percentile), group 5 (80th-98.9th percentile), and group 6 ( >= 99th percentile). Systolic and diastolic hypertensions were defined as >= 140mmHg and >= 85mmHg, respectively. Resting tachycardia was defined as the corresponding 95th percentile or greater. Resting HR and systolic and diastolic blood pressures increased with adiposity level in both sexes (p < 0.0001). Both systolic HT and diastolic HT were associated with high resting HR, and the clustering of these unfavorable conditions increased with the degree of obesity.Conclusion Hemodynamic abnormalities, such as HT and a high resting HR, are closely associated with adolescent obesity and are probably explained by impaired autonomic nerve function.