Chitotriosidase and soluble IL-2 receptor: Comparison of two markers of sarcoidosis severity
Chitotriosidase and soluble IL-2 receptor: Comparison of two markers of sarcoidosis severity
复制标题
DOI：
10.1080/00365510701854975
复制
发表时间：
2008-01-01
影响因子：
2.1
通讯作者：
Rottoli, Paola
中科院分区：
文献类型：
--
作者：
Bargagli, Elena;Bianchi, Nicola;Rottoli, Paola
背景结节病是一种多系统性肉芽肿性疾病，其临床过程不可预测，其特征是活化的增殖T淋巴细胞和单核吞噬细胞在受累器官中的积聚。目标和方法。本研究的目的是描述在锡耶纳结节病区域中心随访的结节病患者的临床、放射学和免疫学特征，并分析这些患者血清中壳三糖苷酶和sIL-2 R的浓度，以了解其作为疾病标志物的潜力。结果结节病患者血清中壳三糖苷酶和sIL-2 R水平显著高于健康对照组（P
Background. Sarcoidosis is a multisystemic granulomatous disease with an unpredictable clinical course characterized by accumulation of activated proliferating T lymphocytes and mononuclear phagocytes in affected organs. Aims and methods . The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients followed at the Sarcoidosis Regional Centre in Siena and to analyse chitotriosidase and sIL-2R concentrations in serum of these patients in order to understand their potential as disease markers. Results . Chitotriosidase and sIL-2R concentrations in serum of sarcoidosis patients were found to be significantly higher than in healthy controls (p