Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: Ten-Year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853 - A study by the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group
Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: Ten-Year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853 - A study by the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group
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DOI：
10.1200/jco.2006.06.1366
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发表时间：
2006-07-20
影响因子：
45.3
通讯作者：
Rutgers, Emiel J. Th.
中科院分区：
文献类型：
--
作者：
Bijker, Nina;Meijnen, Philip;Rutgers, Emiel J. Th.
目的欧洲癌症研究和治疗组织进行了一项随机试验，研究乳腺导管原位癌（DCIS）局部切除（LE）后放疗（RT）的作用。我们分析了RT的疗效与10年随访的局部复发（LR）的总体风险和相关的临床，组织学，和治疗factors.Patients和MethodsAfter完整LE，女性DCIS随机分配到没有进一步的治疗或RT（50戈伊）。纳入了1010名大多数（71%）乳腺X线检查发现DCIS的女性。中位随访时间为10.5年。结果10年无LR率在单纯LE治疗组为74%，而在LE加RT治疗组为85%（对数秩P
PurposeThe European Organisation for Research and Treatment of Cancer conducted a randomized trial investigating the role of radiotherapy (RT) after local excision (LE) of ductal carcinoma-in-situ (DCIS) of the breast. We analyzed the efficacy of RT with 10 years follow-up on both the overall risk of local recurrence (LR) and related to clinical, histologic, and treatment factors.Patients and MethodsAfter complete LE, women with DCIS were randomly assigned to no further treatment or RT (50 Gy). One thousand ten women with mostly (71%) mammographically detected DCIS were included. The median follow-up was 10.5 years.ResultsThe 10-year LR-free rate was 74% in the group treated with LE alone compared with 85% in the women treated by LE plus RT (log-rank P