Increased circulating levels of insulin-like growth factor-I and decreased circulating levels of insulin-like growth factor binding protein-1 in postmenopausal women with endometrial cancer
Increased circulating levels of insulin-like growth factor-I and decreased circulating levels of insulin-like growth factor binding protein-1 in postmenopausal women with endometrial cancer
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DOI：
10.1507/endocrj.44.419
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发表时间：
1997-06-01
影响因子：
2
通讯作者：
Taketani, Y
中科院分区：
文献类型：
--
作者：
Ayabe, T;Tsutsumi, O;Taketani, Y
在人子宫内膜中，胰岛素样生长因子结合蛋白（IGFBP）-1通过抑制胰岛素样生长因子（IGF-I）与其受体的结合来抑制胰岛素样生长因子（IGF）-I的促有丝分裂作用。我们的目的是比较有和没有子宫内膜癌的妇女中IGF-I和IGFBP-1的循环水平。我们评估了23名子宫内膜癌患者、11名宫颈癌患者和27名健康对照妇女的IGF-I、IGFBP-1和IGFBP-3循环水平。绝经后IGF-I的平均循环水平显著降低，但与对照组的年龄无关。子宫内膜癌组的体重指数显著高于对照组。协方差分析显示，即使调整数据以消除体重指数的影响，绝经后子宫内膜癌患者的循环IGF-I浓度仍高于绝经后对照受试者。绝经后癌症患者IGFBP-1的平均循环水平显著低于绝经后对照组。宫颈癌患者血清IGF-I和IGFBP-1水平与对照组比较差异无统计学意义。总之，循环中IGF-I浓度升高和IGFBP-1浓度降低与子宫内膜癌相关，尤其是在绝经后妇女中。
In human endometrium insulin-like growth factor binding protein (IGFBP)-1 inhibits the mitogenic action of insulin-like growth factor (IGF)-I by inhibiting the binding of IGF-I to its receptor. Our purpose was to compare circulating levels of IGF-I and IGFBP-1 in women with and without endometrial cancer. We assessed circulating levels of IGF-I and IGFBP-1 and IGFBP-3 in 23 patients with endometrial cancer, 11 patients with uterine cervical cancer and 27 healthy control women. The mean circulating level of IGF-I decreased significantly following menopause but was not correlated with age in the control group. The body mass index was significantly higher in the endometrial cancer group than in the control group. Analysis of covariance showed that even after the data were adjusted to eliminate the influence of the body mass index, the circulating IGF-I concentration was higher in postmenopausal endometrial cancer patients than in postmenopausal control subjects. The mean circulating level of IGFBP-1 was significantly lower in postmenopausal cancer patients than in postmenopausal control subjects. There were no significant differences in the serum levels of IGF-I and IGFBP-1 in the patients with cervical cancer and the control group. In conclusion, an increased circulating concentration of IGF-I and a decreased circulating concentration of IGFBP-1 are associated with endometrial cancer especially in postmenopausal women.