Temporal Envelope Coding of the Human Auditory Nerve Inferred from Electrocochleography: Comparison with Envelope Following Responses.
Temporal Envelope Coding of the Human Auditory Nerve Inferred from Electrocochleography: Comparison with Envelope Following Responses.
复制标题
从耳蜗电图推断的人类听觉神经的时间包络编码：与包络跟随响应的比较。
DOI：
10.1007/s10162-022-00865-z
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Jennings,SkylerG
中科院分区：
文献类型：
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作者：
Chen,Jessica;Jennings,SkylerG
声音缓慢幅度波动（即时间包络）的神经编码被认为对于语音理解至关重要；然而，人们对人类听觉神经的这种编码知之甚少。在这里，人类听觉神经对颞叶包络的神经编码是根据对 20 至 1000 Hz 调制频率的调幅载波 (CAPENV) 的复合动作电位的测量来推断的。包络跟随响应 (EFR) 与 CAPENV 同时测量，分别来自放置在高额头和鼓膜上的有源电极。结果支持这样的假设：与 EFR 相比，CAPENV 的锁相到更高调制频率 (> 80 Hz) 的能力更强，这与听觉脑干/皮层神经元相比听觉神经纤维的锁相频率上限一致。未来的工作需要确定（1）CAPENV 是一个有用的工具，用于研究听神经的时间处理如何受到衰老、听力损失和噪声引起的耳蜗突触病的影响；（2）CAPENV 揭示了听神经时间处理和颞叶包络感知之间的关系。
Neural coding of the slow amplitude fluctuations of sound (i.e., temporal envelope) is thought to be essential for speech understanding; however, such coding by the human auditory nerve is poorly understood. Here, neural coding of the temporal envelope by the human auditory nerve is inferred from measurements of the compound action potential in response to an amplitude modulated carrier (CAPENV) for modulation frequencies ranging from 20 to 1000 Hz. The envelope following response (EFR) was measured simultaneously with CAPENVfrom active electrodes placed on the high forehead and tympanic membrane, respectively. Results support the hypothesis that phase locking to higher modulation frequencies (> 80 Hz) will be stronger for CAPENV, compared to EFR, consistent with the upper-frequency limits of phase locking for auditory nerve fibers compared to auditory brainstem/cortex neurons. Future work is needed to determine the extent to which (1) CAPENVis a useful tool for studying how temporal processing of the auditory nerve is affected by aging, hearing loss, and noise-induced cochlear synaptopathy and (2) CAPENVreveals the relationship between auditory nerve temporal processing and perception of the temporal envelope.