Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1
Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1
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DOI：
10.1016/j.neurobiolaging.2014.11.002
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发表时间：
2015-03-01
影响因子：
4.2
通讯作者：
Wang, Siwang
中科院分区：
文献类型：
--
作者：
Zhou, Xuanxuan;Yang, Qian;Wang, Siwang
中草药黄精（Polygonatum multiflorum）有延长动物寿命的作用，但其分子机制尚不清楚。四羟基二苯乙烯葡萄糖苷（TSG）是何首乌的主要成分之一，可能有助于延长哺乳动物的寿命。另一方面，神经元胰岛素信号介导哺乳动物的寿命。因此，我们研究了TSG对加速衰老易感小鼠（SAMP 8）记忆能力、寿命和神经胰岛素信号的影响。与对照组相比，TSG组记忆能力明显改善（P < 0.01）。与对照组相比，TSG最多延长SAMP 8的寿命17%（p < 0.01）。TSG增加SAMP 8脑中神经klotho的蛋白水平，并降低神经胰岛素、胰岛素受体、胰岛素样生长因子-1和胰岛素样生长因子-1受体的水平（p < 0.01，与对照组相比）。这些蛋白质都是神经胰岛素/IGF-1信号通路的关键因子。这些结果表明，TSG对哺乳动物具有抗衰老作用。结果表明，何首乌总皂苷有可能成为一种潜在的抗衰老药物。(C)2015 Elsevier Inc. All rights reserved.
A Chinese herb, Polygonatum multiflorum, has been reported to prolong animal life span, but the relevant molecular mechanism remains unclear. Tetrahydroxystilbene glucoside (TSG) is one main component of P. multiflorum and may contribute to extending life span of mammals. On the other hand, neuronal insulin signaling mediates the life span of mammals. Therefore, we investigated the effects of TSG on memory ability, life span, and the neural insulin signaling in the senescence-accelerated prone mouse (SAMP8). TSG improved the memory ability significantly (p < 0.01, compared with a control group). TSG prolonged the life span of SAMP8 by 17% at the most (p < 0.01, compared with a control group). TSG increased the protein level of neural klotho and reduced the levels of neural insulin, insulin-receptor, insulin-like growth factor-1, and insulin-like growth factor-1 receptor in the brain of SAMP8 (p < 0.01, compared with a control group). All these proteins are key factors of the pathways related to neural insulin/IGF-1 signaling. These findings suggest that TSG has anti-aging effects on mammals. From these results, TSG from P. multiflorum should be developed as a potential anti-age drug. (C) 2015 Elsevier Inc. All rights reserved.