Expression of Sox genes in tooth development.
Expression of Sox genes in tooth development.
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DOI：
10.1387/ijdb.150192ao
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Ohazama A
中科院分区：
文献类型：
--
作者：
Kawasaki K;Kawasaki M;Watanabe M;Idrus E;Nagai T;Oommen S;Maeda T;Hagiwara N;Que J;Sharpe PT;Ohazama A
SOX基因家族成员在包括器官发生在内的许多生物学过程中发挥作用。我们对17个Sox基因(Sox1-14、17、18、21)进行了比较原位杂交分析。5个Sox基因(Sox6、9、13、14和21)在牙蕾上皮细胞中有定位表达。SOX13在初级釉质结中表达受限。在钟状早期，3个Sox基因(Sox8、11、17和21)在成釉细胞中表达，而另外两个基因(Sox5和18)在成牙本质细胞中表达。因此，SOX基因在牙齿发育过程中表现出动态的时空表达。
Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.