An H9N2 Influenza Virus Vaccine Prepared from a Non-Pathogenic Isolate from a Migratory Duck Confers Protective Immunity in Mice against Challenge with an H9N2 Virus Isolated from a Girl in Hong Kong
An H9N2 Influenza Virus Vaccine Prepared from a Non-Pathogenic Isolate from a Migratory Duck Confers Protective Immunity in Mice against Challenge with an H9N2 Virus Isolated from a Girl in Hong Kong
复制标题
DOI：
10.1292/jvms.11-0471
复制
发表时间：
2012-04-01
影响因子：
1.2
通讯作者：
Kida, Hiroshi
中科院分区：
文献类型：
--
作者：
Nomura, Naoki;Sakoda, Yoshihiro;Kida, Hiroshi
H9 N2流感病毒在欧亚国家的野鸟和家禽中传播，并已在中国的猪和人身上分离出来。从禽鸟、猪只及人类分离的H9 N2病毒，根据抗原性及基因特徴分为三个亚系。鸡抗H9 N2病毒的韩国亚系的反应与不同的亚系的病毒的血凝抑制试验。从我们的流感病毒库中获得的韩国亚系的非致病性A/duck/北海道/49/1998（H9 N2）毒株制备的试验疫苗诱导小鼠产生免疫力，以降低A/Hong Kong/1073/1999（H9 N2）（属于不同亚系）攻毒引起的疾病影响。本研究结果表明，从库中的非致病性流感病毒制备的灭活全病毒疫苗可用作H9 N2感染引起的大流行的早期阶段的应急疫苗。
H9N2 influenza viruses circulate in wild birds and poultry in Eurasian countries, and have been isolated from pigs and humans in China. H9N2 viruses isolated from birds, pigs and humans have been classified into three sublineages based on antigenic and genetic features. Chicken antisera to H9N2 viruses of the Korean sublineage reacted with viruses of different sublineages by the hemagglutination-inhibition test. A test vaccine prepared from a non-pathogenic A/duck/Hokkaido/49/1998 (H9N2) strain of the Korean sublineage, obtained from our influenza virus library, induced immunity in mice to reduce the impact of disease caused by the challenge with A/Hong Kong/1073/1999 (H9N2), which is of a different sublineage. The present results indicate that an inactivated whole virus vaccine prepared from a non-pathogenic influenza virus from the library could be used as an emergency vaccine during the early stage of a pandemic caused by H9N2 infection.