A neurocentric perspective on glioma invasion.
A neurocentric perspective on glioma invasion.
复制标题
DOI：
10.1038/nrn3765
复制
发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Sontheimer H
中科院分区：
文献类型：
--
作者：
Cuddapah VA;Robel S;Watkins S;Sontheimer H
恶性神经胶质瘤是一种毁灭性的肿瘤，经常在诊断后1年内杀死患者。治愈的主要障碍是扩散性侵袭，这使得肿瘤能够逃脱完全的手术切除和化疗和放疗。神经胶质瘤使用与未成熟神经元和干细胞相同的曲折细胞外迁移路线，经常使用血管作为引导。他们重新利用离子通道来动态调整细胞体积，以适应狭窄的空间，并通过破坏包裹血管的星形胶质细胞终足来突破血脑屏障。胶质瘤侵袭的独特生物学为这种毁灭性疾病提供了迄今未开发的脑特异性治疗靶点。
Malignant gliomas are devastating tumours that frequently kill patients within 1 year of diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to escape complete surgical resection and chemo- and radiation therapy. Gliomas use the same tortuous extracellular routes of migration that are travelled by immature neurons and stem cells, frequently using blood vessels as guides. They repurpose ion channels to dynamically adjust their cell volume to accommodate to narrow spaces and breach the blood-brain barrier through disruption of astrocytic endfeet, which envelop blood vessels. The unique biology of glioma invasion provides hitherto unexplored brain-specific therapeutic targets for this devastating disease.