Fluorescent Intensity and Lifetime Measurement of Platinum-Porphyrin Film for Determining the Sensitivity of Transcutaneous Oxygen Sensor
Fluorescent Intensity and Lifetime Measurement of Platinum-Porphyrin Film for Determining the Sensitivity of Transcutaneous Oxygen Sensor
复制标题
铂卟啉薄膜的荧光强度和寿命测量用于确定经皮氧传感器的灵敏度
DOI：
10.1109/iscas45731.2020.9180902
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
U. Guler
中科院分区：
文献类型：
--
作者：
I. Costanzo;Devdip Sen;B. Giri;N. Pratt;P. Rao;U. Guler
在大多数基于光学的氧传感器中，荧光猝灭被用作传感原理。强度和寿命是用于量化测量参数的两种已知测量技术。寿命测量技术具有上级特征，例如对光路的变化、膜的退化或光漂白的敏感性很小或不敏感。在这项研究中，我们进行了一个实验，分析性能的强度和寿命测量技术的铂卟啉荧光膜，传感材料，在不同浓度的氧气。一个原型，部署一个模拟前端，发光二极管驱动器，和电源管理块上实现的印刷电路板与商业现成的组件。该系统可分辨0.5 mmHg至500 mmHg的氧气压力变化，功耗为132 mW。该系统可潜在地用于测量通过皮肤扩散的氧气浓度，也称为氧气的经皮测量。这些测量是开发更复杂的读出电路的关键，用于可靠和灵敏的医疗目的经皮氧感测。
In most optical-based oxygen sensors, fluorescent quenching is used as the sensing principle. Intensity and lifetime are two known measurement techniques that are employed to quantify the measured parameter. The lifetime measurement technique has superior features such as little or no sensitivity to changes in the optical path, degradation of the film or photo-bleaching. In this study, we conducted an experiment to analyze the performance of both the intensity and lifetime measurement techniques of a platinum-porphyrin fluorescent film, the sensing material, under different concentrations of oxygen. A prototype that deploys an analog front-end, a light emitting diode driver, and a power management block is implemented on a printed circuit board with commercial off-the-shelf components. The system resolves changes in oxygen pressure from 0.5 mmHg to 500 mmHg with a power consumption of 132 mW. This system could be potentially used to measure the concentration of oxygen diffused through the skin, also known as transcutaneous measurement of oxygen. These measurements are key to developing more sophisticated read-out circuits for reliable and sensitive medical purpose transcutaneous oxygen sensing.