Electrophysiological correlates of the brain's intrinsic large-scale functional architecture
Electrophysiological correlates of the brain's intrinsic large-scale functional architecture
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DOI：
10.1073/pnas.0807010105
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发表时间：
2008-10-14
影响因子：
11.1
通讯作者：
Raichle, Marcus E.
中科院分区：
文献类型：
--
作者：
He, Biyu J.;Snyder, Abraham Z.;Raichle, Marcus E.
血氧水平依赖（BOLD）信号的自发波动在与不同功能相关的大规模脑网络内显示出一致的时间相关性。这种现象的神经生理学关联仍不明确。在此，我们在人类中表明，皮质脑电图记录的慢皮质电位在清醒、慢波睡眠和快速眼动睡眠期间呈现出与自发BOLD波动相似的相关结构。伽马频段功率也显示出类似的相关结构，但仅在清醒和快速眼动睡眠期间。我们的研究结果在自发BOLD信号容易揭示的大规模脑网络与其潜在的神经生理学之间搭建了一座重要的桥梁。
Spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signals demonstrate consistent temporal correlations within large-scale brain networks associated with different functions. The neurophysiological correlates of this phenomenon remain elusive. Here, we show in humans that the slow cortical potentials recorded by electrocorticography demonstrate a correlation structure similar to that of spontaneous BOLD fluctuations across wakefulness, slow-wave sleep, and rapid-eye-movement sleep. Gamma frequency power also showed a similar correlation structure but only during wakefulness and rapid-eye-movement sleep. Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology.