Pathways for fear perception: Modulation of amygdala activity by thalamo-cortical systems
Pathways for fear perception: Modulation of amygdala activity by thalamo-cortical systems
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DOI：
10.1016/j.neuroimage.2005.01.049
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发表时间：
2005-05-15
期刊：
影响因子：
5.7
通讯作者：
Williams, LM
中科院分区：
文献类型：
--
作者：
Das, P;Kemp, AH;Williams, LM
有效地感知恐惧信号对人类的生存至关重要，杏仁核在这一过程中的重要性已经得到了很好的证明。动物、损伤和神经影像学研究表明，传入的恐惧感觉信号通过两条神经通路从丘脑传播到杏仁核：一条是直接的皮层下通路，另一条是通过感觉皮层的间接通路。其他的研究已经证明了杏仁核的前额调制。然而，迄今为止还没有研究探讨了在体内的丘脑-皮质-杏仁核通路的前额叶调制。我们使用心理生理学和生理生理学的相互作用，以检查丘脑，杏仁核和感觉（枕下，梭形）皮质内的功能连接，以及这些网络的调制由前扣带皮层（ACC）。功能性磁共振成像（fMRI）数据采集28名健康对照受试者在恐惧知觉任务，中性作为“基线”控制条件。使用感兴趣区域（ROI）方法进行的主效应分析证实，这些区域是恐惧感知的分布式神经系统的一部分。心理生理学的相互作用揭示了枕颞视觉区和左杏仁核之间的反向功能连接，但这些视觉区和右杏仁核之间的正向连接，这表明有一个半球的专业化在转移恐惧信号从感觉皮层到杏仁核。生理相互作用揭示了ACC调节丘脑-感觉皮层通路的背腹分裂。虽然背侧ACC表现出积极的调制这一途径，腹侧ACC表现出相反的关系。此外，背侧和腹侧ACC都表现出与直接丘脑-杏仁核通路的反向相互作用。这些研究结果表明，丘脑-杏仁核和皮质区域参与了动态的相互作用，在偏侧和腹侧/背侧梯度的功能分化。这些相互作用的中断可能会引起一系列神经精神疾病中出现的与情感相关的症状。(c)2005年爱思唯尔公司All rights reserved.
Effective perception of fear signals is crucial for human survival and the importance of the amygdala in this process is well documented. Animal, lesion and neuroimaging studies indicate that incoming sensory signals of fear travel from thalamus to amygdala via two neural pathways: a direct subcortical route and an indirect pathway via the sensory cortex. Other lines of research have demonstrated prefrontal modulation of the amygdala. However, no study to date has examined the prefrontal modulation of the thalamo-cortico-amygdala pathways in vivo. We used psychophysiological and physiophysiological interactions to examine the functional connectivity within thalamus, amygdala and sensory (inferior occipital, fusiform) cortices, and the modulation of these networks by the anterior cingulate cortex (ACC). Functional magnetic resonance imaging (fMRI) data were acquired for 28 healthy control subjects during a fear perception task, with neutral as the 'baseline' control condition. Main effect analysis, using a region of interest (ROI) approach, confirmed that these regions are part of a distributed neural system for fear perception. Psychophysiological interactions revealed an inverse functional connectivity between occipito-temporal visual regions and the left amygdala, but a positive connectivity between these visual region and the right amygdala, suggesting that there is a hemispheric specialization in the transfer of fear signals from sensory cortices to amygdala. Physiophysiological interactions revealed a dorsal-ventral division in ACC modulation of the thalamus-sensory cortex pathway. While the dorsal ACC showed a positive modulation of this pathway, the ventral ACC exhibited an inverse relationship. In addition, both the dorsal and ventral ACC showed an inverse interaction with the direct thalamusamygdala pathway. These findings suggest that thalamo-amygdala and cortical regions are involved in a dynamic interplay, with functional differentiation in both lateralized and ventral/dorsal gradients. Break-downs in these interactions may give rise to affect-related symptoms seen in a range of neuropsychiatric disorders. (c) 2005 Elsevier Inc. All rights reserved.