Designing helical peptide inhibitors of protein-protein interactions.
Designing helical peptide inhibitors of protein-protein interactions.
复制标题
设计蛋白质 - 蛋白质相互作用的螺旋肽抑制剂。
DOI：
10.1016/j.sbi.2016.04.001
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发表时间：
2016-08
影响因子：
6.8
通讯作者：
Keating AE
中科院分区：
文献类型：
--
作者：
Rezaei Araghi R;Keating AE
短螺旋肽结合了小分子和大蛋白质的特点，为蛋白质设计提供了一个令人兴奋的机会。越来越多的研究报道了新的螺旋肽抑制剂的蛋白质-蛋白质相互作用。新技术已经发展为肽设计和化学稳定肽在螺旋构象，经常提高蛋白酶抗性和细胞的通透性。我们总结了肽交联化学的进展，并举例说明了针对盘绕转录因子、Bcl-2家族蛋白、MDM2/MDMX和HIV gp41等靶点的肽设计研究。
Short helical peptides combine characteristics of small molecules and large proteins and provide an exciting area of opportunity in protein design. A growing number of studies report novel helical peptide inhibitors of protein-protein interactions. New techniques have been developed for peptide design and for chemically stabilizing peptides in a helical conformation, which frequently improves protease resistance and cell permeability. We summarize advances in peptide crosslinking chemistry and give examples of peptide design studies targeting coiled-coil transcription factors, Bcl-2 family proteins, MDM2/MDMX, and HIV gp41, among other targets.