Multiple roles of Sox2, an HMG‐box transcription factor in avian neural crest development
Multiple roles of Sox2, an HMG‐box transcription factor in avian neural crest development
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DOI：
10.1002/dvdy.10498
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发表时间：
2004-01
影响因子：
2.5
通讯作者：
Y. Wakamatsu;Yukinori Endo;N. Osumi;J. A. Weston
中科院分区：
文献类型：
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作者：
Y. Wakamatsu;Yukinori Endo;N. Osumi;J. A. Weston
当神经嵴与背神经管分离时，编码HMG盒型转录因子的Sox 2的表达在神经板中下调，并且在嵴细胞迁移期间保持低水平。Sox 2表达随后在发育中的外周神经系统中的一些嵴源性细胞中上调，并且随后限于胶质细胞亚系。Sox 2和突变形式的Sox 2在神经板外植体和胚胎外胚层中的错误表达揭示了Sox 2作为转录激活剂抑制神经嵴形成。在迁移和迁移后神经嵴衍生细胞中Sox 2功能的类似操作表明，Sox 2调节发育中的外周神经系统的增殖和分化。Developmental Dynamics 229：74-86，2004.© 2003 Wiley利斯公司
Expression of Sox2, which encodes an HMG‐box–type transcription factor, is down‐regulated in the neural plate when neural crest segregates from dorsal neural tube and remains low during crest cell migration. Sox2 expression is subsequently up‐regulated in some crest‐derived cells in the developing peripheral nervous system and is later restricted to glial sublineages. Misexpression of Sox2 and mutant forms of Sox2 both in neural plate explants and in embryonic ectoderm reveals that Sox2 inhibits neural crest formation as a transcriptional activator. Similar manipulation of Sox2 function in migratory and postmigratory neural crest‐derived cells indicates that Sox2 regulates proliferation and differentiation in developing peripheral nervous system. Developmental Dynamics 229:74–86, 2004. © 2003 Wiley‐Liss, Inc.