Tianeptine attenuates stress-induced morphological changes in the hippocampus.
Tianeptine attenuates stress-induced morphological changes in the hippocampus.
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DOI：
10.1016/0014-2999(92)90830-w
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发表时间：
1992-11
影响因子：
5
通讯作者：
Y. Watanabe;E. Gould;D. Daniels;H. Cameron;B. McEwen
中科院分区：
文献类型：
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作者：
Y. Watanabe;E. Gould;D. Daniels;H. Cameron;B. McEwen
重复6小时的日常约束应力超过21天减少长度和数量的分支点的海马CA 3c锥体树突在成年雄性大鼠海马结构。每日注射40 mg/kg皮质酮可模拟该效应。每日治疗噻奈普汀（15毫克/公斤）之前的压力会议或皮质酮治疗，防止这些影响的压力或皮质酮，分别。噻奈普汀治疗不能阻止应激增加肾上腺/体重比的作用，也不能阻止应激减少体重增加的作用，表明其作用不仅仅是通过对应激诱导的皮质酮分泌的作用介导的。由于噻奈普汀是已知的，以提高神经摄取的5-羟色胺，这些结果表明，多巴胺能系统可能参与调节应激和皮质酮对树突形态的影响。
Repeated 6-h daily restraint stress over 21 days reduces length and number of branch points of hippocampal CA3c pyramidal dendrites in the hippocampal formation of adult male rats. This effect is mimicked by daily injections of 40 mg/kg corticosterone. Daily treatment with tianeptine (15 mg/kg) prior to stress sessions or the corticosterone treatment prevented these effects of stress or corticosterone, respectively. Tianeptine treatment did not prevent the effects of stress to increase adrenal/body weight ratio, nor did it prevent the effects of stress to decrease body weight gain, indicating that its actions are not mediated solely by effects on stress-induced secretion of corticosterone. Because tianeptine is known to enhance neural uptake of serotonin, these results suggest that the serotonergic system may be involved in modulating stress and corticosterone effects on dendritic morphology.