Neurocognitive Functioning in Women with a History of Eclampsia: Executive Functioning and Sustained Attention
Neurocognitive Functioning in Women with a History of Eclampsia: Executive Functioning and Sustained Attention
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DOI：
10.1055/s-0030-1253099
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发表时间：
2010-10-01
影响因子：
2
通讯作者：
Zeeman, Gerda G.
中科院分区：
文献类型：
--
作者：
Postma, Ineke R.;Wessel, Ineke;Zeeman, Gerda G.
最近，有信息表明，以前的子痫妇女可能会遭受认知障碍。这可能与大脑白色病变有关。现有的几份报告显示了不一致的结果。我们试图在一项初步研究中阐明子痫后的认知表现。26名子痫患者、20名先兆子痫患者和18名健康的经产妇女进行了持续注意力反应任务（SART;维持对重复刺激的正念处理的能力，否则会导致习惯化）和随机数生成任务（RNG;执行功能，即，抑制和更新/监测）。平均年龄为40岁，自首次妊娠以来的时间为9年。教育水平没有差别。无并发症。SART和RNG评分组间差异无统计学意义。这项研究无法证明子痫后持续注意力和执行功能受损的证据。研究包括更广泛的神经认知测试，扩大到更大群体的后脑区域是必要的。
Recently, information has emerged that formerly eclamptic women may suffer cognitive impairment. This may be related to cerebral white matter lesions. The few available reports demonstrate inconsistent results. We sought to elucidate cognitive performance after eclampsia in a pilot study. Twenty-six eclamptic, 20 preeclamptic, and 18 healthy parous women performed the Sustained Attention to Response Task (SART; the ability to sustain mindful processing of repetitive stimuli that would otherwise lead to habituation) and the Random Number Generation Task (RNG; executive functioning, i.e., inhibition and updating/monitoring). Average age was 40 years, elapsed time since index pregnancy was 9 years. Education levels did not differ. There were no intercurrent illnesses. No significant differences were found on SART and RNG scores between groups. This study was not able to demonstrate evidence for impaired sustained attention and executive functioning after eclampsia. Studies including a much wider range of neurocognitive tests amplified to posterior brain regions with larger groups are necessary.