Functional mechanism of bHLH complexes during early vascular development.
Functional mechanism of bHLH complexes during early vascular development.
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DOI：
10.1016/j.pbi.2016.06.003
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发表时间：
2016-10
影响因子：
9.5
通讯作者：
Kyoko Ohashi-Ito;H. Fukuda
中科院分区：
文献类型：
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作者：
Kyoko Ohashi-Ito;H. Fukuda
LHW-TMO 5与生长素和细胞分裂素的活性密切相关，LHW-TMO 5通过负反馈回路调节其输出水平。维管系统遍布植物体。这个高度组织化的网络包含几种类型的细胞。维管细胞发育在胚胎发生期间开始，然后维管细胞增殖，形成维管模式，并致力于特定的细胞命运。最近的分子遗传学和建模方法增加了我们对早期血管发育的分子机制的理解。在血管发育过程中的早期事件是紧密相连的，并由转录复合物组成的LONESOME高速公路（LHW）和目标的monopteros 5（TMO 5）家庭控制。LHW-TMO 5的作用与植物激素如生长素和细胞分裂素的生物合成和/或信号传导紧密相关。本文就LHW-TMO 5在早期血管发育中的调控网络进行综述。
HighlightsEarly vascular development involves proliferation, patterning and fate commitment.A LHW-TMO5 bHLH complex plays a central role in early vascular development.Regulation of auxin and cytokinin activities is tightly linked with LHW-TMO5.Negative feedback loop regulates the output levels of LHW-TMO5.The vascular system spreads throughout the plant body. This highly organized network contains several types of cells. Vascular cell development is initiated during embryogenesis, and then vascular cells proliferate, form a vascular pattern, and commit to specific cell fates. Recent molecular genetics and modeling approaches have increased our understanding of the molecular mechanisms underlying early vascular development. Early events during vascular development are tightly linked and controlled by transcriptional complexes consisting of LONESOME HIGHWAY (LHW) and TARGET OF MONOPTEROS5 (TMO5) families. The role of LHW-TMO5 is tightly coupled with biosynthesis and/or signaling of phytohormones such as auxin and cytokinin. In this review, we discuss the regulatory network mediated by LHW-TMO5 during early vascular development.