Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro
Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro
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DOI：
10.1080/14756360802667977
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发表时间：
2009-10-01
影响因子：
5.6
通讯作者：
Kim, Young Choong
中科院分区：
文献类型：
--
作者：
Kim, Seung Hyun;Lee, Mi Kyeong;Kim, Young Choong
牡丹根甲醇提取物对过氧化氢诱导的原代培养大鼠皮质细胞氧化应激有明显的保护作用。采用生物活性导向的分离和层析技术，分离得到7个单萜类化合物，分别为丹皮内酯-B(1)、丹皮内酯-C(2)、芍药内酯(3)、苯甲酰芍药苷(4)、芍药苷(5)、氧化牡丹内酯(6)和白藜芦苷(7)。其中，化合物2和4可显著保护原代培养的大鼠皮质细胞免受过氧化氢所致的神经毒性。
The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H2O2. Seven monoterpenes, paeonilactone-B (1), paeonilactone-C (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. Among them, compounds 2 and 4 significantly protected primary cultures of rat cortical cells against H2O2-induced neurotoxicity.