Reversible Switching of Cooperating Replicators.
Reversible Switching of Cooperating Replicators.
复制标题
协作复制器的可逆切换。
DOI：
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复制
发表时间：
2017
影响因子：
8.6
通讯作者：
D. Braun
中科院分区：
文献类型：
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作者：
Georg Urtel;Thomas Rind;D. Braun
寿命短的分子如何在数百万年内保存其信息？为了使进化发生，携带信息的分子必须在降解之前复制。我们的实验揭示了一个强大的，可逆的合作机制，在寡核苷酸复制。两个天生复制缓慢的发夹分子可以将它们的信息传递给快速杂交的复制子，这些复制子比发夹长得快。反过来也是可能的。当一个复制起始位点缺失时，杂交品种中会重新出现单个发夹。通过这种机制，相互作用的复制子可以在发夹模式和杂交模式之间切换，揭示了对不同边界条件的灵活适应。
How can molecules with short lifetimes preserve their information over millions of years? For evolution to occur, information-carrying molecules have to replicate before they degrade. Our experiments reveal a robust, reversible cooperation mechanism in oligonucleotide replication. Two inherently slow replicating hairpin molecules can transfer their information to fast crossbreed replicators that outgrow the hairpins. The reverse is also possible. When one replication initiation site is missing, single hairpins reemerge from the crossbreed. With this mechanism, interacting replicators can switch between the hairpin and crossbreed mode, revealing a flexible adaptation to different boundary conditions.