Tools and techniques for illuminating the cell biology of zinc.

Tools and techniques for illuminating the cell biology of zinc.
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阐明锌细胞生物学的工具和技术。

DOI:
10.1016/j.bbamcr.2020.118865
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发表时间:
2021-01
期刊:
Biochimica et biophysica acta. Molecular cell research
影响因子:
--
通讯作者:
Palmer AE
Palmer AE
中科院分区:
其他
文献类型:
--
作者:
Pratt EPS;Damon LJ;Anson KJ;Palmer AE

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Zinc (Zn2+) is an essential micronutrient that is required for a wide variety of cellular processes. Tools and methods have been instrumental in revealing the myriad roles of Zn2+ in cells. This review highlights recent developments fluorescent sensors to measure the labile Zn2+ pool, chelators to manipulate Zn2+ availability, and fluorescent tools and proteomics approaches for monitoring Zn2+-binding proteins in cells. Finally, we close with some highlights on the role of Zn2+ in regulating cell function and in cell signaling.
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