Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance.
Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance.
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DOI：
10.1007/978-3-319-42023-3_8
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发表时间：
2016
影响因子：
--
通讯作者：
Rejniak, Katarzyna A.
中科院分区：
文献类型：
--
作者：
Perez-Velazquez, Judith;Gevertz, Jana L.;Karolak, Aleksandra;Rejniak, Katarzyna A.
功能异常的肿瘤血管导致肿瘤组织内代谢产物和药物的不规则梯度。最近，大量的努力致力于实验研究细胞对抗癌治疗的反应如何基于细胞生长的环境而变化。体外研究指出，在特定的条件下，肿瘤细胞可以保持休眠状态，并在治疗后存活。在体内的结果表明，细胞可以在药物渗透较差的组织区域逃脱药物治疗的影响。更好地了解肿瘤微环境如何影响原发和转移肿瘤中耐药的出现，可能会改善药物开发和更有效的治疗方案的设计。本章提出了一个基于混合制剂的肿瘤微转移生长模型，并探索了微环境因素如何有助于对DNA损伤药物的获得性耐药性的发展。在这项工作中感兴趣的特定微环境是肿瘤缺氧区和肿瘤常氧避难所，药物渗透性很差。我们的目标是量化有限的药物运输和静止的细胞存活的空间限制如何有助于耐药肿瘤的发展。
A tumor vasculature that is functionally abnormal results in irregular gradients of metabolites and drugs within the tumor tissue. Recently, significant efforts have been committed to experimentally examine how cellular response to anti-cancer treatments varies based on the environment in which the cells are grown. In vitro studies point to specific conditions in which tumor cells can remain dormant and survive the treatment. In vivo results suggest that cells can escape the effects of drug therapy in tissue regions that are poorly penetrated by the drugs. Better understanding how the tumor microenvironments influence the emergence of drug resistance in both primary and metastatic tumors may improve drug development and the design of more effective therapeutic protocols. This chapter presents a hybrid agent-based model of the growth of tumor micrometastases and explores how microenvironmental factors can contribute to the development of acquired resistance in response to a DNA damaging drug. The specific microenvironments of interest in this work are tumor hypoxic niches and tumor normoxic sanctuaries with poor drug penetration. We aim to quantify how spatial constraints of limited drug transport and quiescent cell survival contribute to the development of drug resistant tumors.
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对抗癌疗法的耐药性的进化。
影响因子：
2
作者：
Foo, Jasmine;Michor, Franziska
通讯作者：
Michor, Franziska
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
82.9
作者：
Hata AN;Niederst MJ;Archibald HL;Gomez-Caraballo M;Siddiqui FM;Mulvey HE;Maruvka YE;Ji F;Bhang HE;Krishnamurthy Radhakrishna V;Siravegna G;Hu H;Raoof S;Lockerman E;Kalsy A;Lee D;Keating CL;Ruddy DA;Damon LJ;Crystal AS;Costa C;Piotrowska Z;Bardelli A;Iafrate AJ;Sadreyev RI;Stegmeier F;Getz G;Sequist LV;Faber AC;Engelman JA
通讯作者：
Engelman JA
DOI：
10.1073/pnas.0501870102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Komarova, NL;Wodarz, D
通讯作者：
Wodarz, D
影响因子：
4.3
作者：
Fu F;Nowak MA;Bonhoeffer S
通讯作者：
Bonhoeffer S