Fibrous networks with incorporated macrocycles: a chiral stimuli-responsive supramolecular supergelator and its application to biocatalysis in organic media.
Fibrous networks with incorporated macrocycles: a chiral stimuli-responsive supramolecular supergelator and its application to biocatalysis in organic media.
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DOI：
10.1002/chem.201300193
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发表时间：
2013-07
期刊：
影响因子：
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通讯作者：
Zhenhui Qi;Changzhu Wu;Paula Malo de Molina;Han-Xue Sun;Andrea Schulz;C. Griesinger;M. Gradzielski
中科院分区：
文献类型：
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作者：
Zhenhui Qi;Changzhu Wu;Paula Malo de Molina;Han-Xue Sun;Andrea Schulz;C. Griesinger;M. Gradzielski
基于双脲基序设计并合成了一种新型多功能、附加冠醚的手性超级凝胶剂。相对于其非手性类似物，立体中心的引入显着提高了其凝胶化能力。这种低分子量胶凝剂可在多种有机溶剂中形成超分子凝胶。它对多种化学刺激敏感，并且溶胶-凝胶相变可以通过主客体相互作用可逆地触发。该凝胶可用于捕获酶并根据化学刺激的需要释放它们。它稳定皮克林乳液中的微粒，以便酶催化的有机反应可以在微粒内部的极性相中发生，有机反应物通过双相界面从周围的有机相扩散。由于有机相和极性相之间的界面面积较大，与简单的双相系统相比，酶活性得到增强。
A new and versatile, crown ether appended, chiral supergelator has been designed and synthesized based on the bis-urea motif. The introduction of a stereogenic center improved its gelation ability significantly relative to its achiral analogue. This low-molecular-weight gelator forms supramolecular gels in a variety of organic solvents. It is sensitive to multiple chemical stimuli and the sol-gel phase transitions can be reversibly triggered by host-guest interactions. The gel can be used to trap enzymes and release them on demand by chemical stimuli. It stabilizes the microparticles in Pickering emulsions so that enzyme-catalyzed organic reactions can take place in the polar phase inside the microparticles, the organic reactants diffusing through the biphasic interface from the surrounding organic phase. Because of the higher interface area between the organic and polar phases, enzyme activity is enhanced in comparison with simple biphasic systems.