TRANSFER OF VARIOUS PCDDS AND PCDFS VIA PLACENTA AND MOTHERS MILK TO MARMOSET OFFSPRING
TRANSFER OF VARIOUS PCDDS AND PCDFS VIA PLACENTA AND MOTHERS MILK TO MARMOSET OFFSPRING
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DOI：
10.1016/0045-6535(90)90222-f
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发表时间：
1990-01-01
期刊：
影响因子：
8.8
通讯作者：
NEUBERT, D
中科院分区：
文献类型：
--
作者：
KROWKE, R;ABRAHAM, K;NEUBERT, D
将多氯二苯并对二恶英和二苯并呋喃(PCDDs和PCDFs)作为一种限定的混合物(其成分与焚烧炉飞灰中发现的相似)皮下注射给一对绒猴(Callithrix Jacchus)。治疗时，雌性绒猴怀孕(排卵约9周)，并在约11周后产下3只后代。研究了多氯联苯并二恶英(PCDDs)和多氯二苯并呋喃(PCDFs)经胎盘和母乳的转运。两名新生儿的肝脏浓度在出生当天进行了测量。在第三个子女和父母中，在33天的哺育期后测定其浓度。对于大多数2，3，7，8-取代的同系物来说，多氯二苯并二恶英和多氯二苯并呋喃通过胎盘的转移很少，特别是对多氯二苯并呋喃。2，3，7，8-T4CDD和1，2，3，7，8-P5CDD的转移率最高。对于所有其他化合物，新生儿肝组织中的浓度低于大坝测量的1/10。婴儿通过母乳接触多氯二苯并二恶英和多氯二苯并呋喃的情况明显高于通过胎盘。经过33天的哺乳，一些2，3，7，8-取代的同系物(2，3，7，8-T4CDD，1，2，3，7，8-P5CDD，1，2，3，6，7，8-H6CDD；1，2，3，7，8，9-H6CDF)在哺乳婴儿体内的肝脏浓度远高于大坝中的相应浓度。在母体和新生儿肝脏中，1，2，3，4，7，8-H6CDD，1，2，3，7，8，9-H6CDD，2，3，4，7，8-P5CDF，1，2，3，4，7，8-H6CDF和1，2，3，6，7，8-H6CDF的浓度大致相同。与母体肝脏相比，婴儿肝脏中2，3，4，6，7，8-H6CDF以及所有七氯和八氯类似物的浓度明显较低。在单次注射后，由于母体组织中的组织浓度很低，2，3，7，8-T4CDF和1，2，3，7，8-P5CDF几乎没有转移到后代。
Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) were given subcutaneously as a defined mixture (with a composition similar to that found in incinerator fly ash) to a marmoset couple (Callithrix jacchus).At the time of treatment the female was pregnant (about 9 weekspost ovulationem) and gave birth to 3 offspring about 11 weeks later. Transfer of PCDDs and PCDFs via placenta and mother's milk was studied. Concentrations in the livers of two newborn were measured on the day of birth. In the third offspring and in the parents the concentrations were determined after a nursing period of 33 days.1.1. For most of the 2,3,7,8-substituted congeners transfer of PCDDs and PCDFs via placenta was very low, especially for the PCDFs. The highest transfer rate was observed for 2,3,7,8-T4CDD and 1,2,3,7,8-P5CDD. For all other compounds concentrations in hepatic tissue of the newborn were lower than 1/10 of those measured in the dam.2.2. Exposure of the baby to PCDDs and PCDFs via mother's milk was clearly higher than via placenta. After a 33-day nursing period hepatic concentrations in the suckled infants for some of the 2,3,7,8-substituted congeners (2,3,7,8-T4CDD, 1,2,3,7,8-P5CDD, 1,2,3,6,7,8-H6CDD; 1,2,3,7,8,9-H6CDF) were well above the corresponding concentrations in the dam. About equal concentrations in maternal and newborn liver were found for 1,2,3,4,7,8-H6CDD, 1,2,3,7,8,9-H6CDD; 2,3,4,7,8-P5CDF, 1,2,3,4,7,8-H6CDF, and 1,2,3,6,7,8-H6CDF. Clearly lower concentrations were reached in the baby's liver when compared with maternal liver for 2,3,4,6,7,8-H6CDF and all the hepta- and octa-chlorinated congeners. Subsequent to the single dose there was practically no transfer of 2,3,7,8-T4CDF and 1,2,3,7,8-P5CDF to the offspring due to the very low tissue concentrations in the maternal organism.