Aortic stiffness and carotid intima-media thickness: two independent markers of subclinical vascular damage in young adults?
Aortic stiffness and carotid intima-media thickness: two independent markers of subclinical vascular damage in young adults?
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DOI：
10.1046/j.1365-2362.2003.01259.x
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发表时间：
2003-11-01
影响因子：
5.5
通讯作者：
Bots, ML
中科院分区：
文献类型：
--
作者：
Oren, A;Vos, LE;Bots, ML
背景 先前的报告表明，颈动脉内膜中层厚度（CIMT）和动脉僵硬度是后续心血管疾病（CVD）发病率和死亡率的有力预测因子，并且与中老年受试者的不良心血管风险状况密切相关。这些相似之处表明动脉僵硬度可能在动脉粥样硬化的发展中发挥作用，反之亦然。然而，研究结果相互矛盾，并且仅限于老年受试者。为了进一步研究这个问题，我们评估了 524 名 27-30 岁健康年轻人的动脉僵硬度与亚临床动脉粥样硬化的关系。方法和结果使用脉搏波速度 (PWV) 评估主动脉僵硬度，并使用 CIMT 作为亚临床动脉粥样硬化的衡量标准。平均动脉压调整后的 PWV 和 CIMT 之间的正粗相关性（皮尔逊相关系数：0.11；P = 0.016）在对性别和年龄等测量的共同决定因素进行调整后减弱（偏相关系数：0.03；P = 0.512）。此外，多元线性回归模型显示，男性性别、年龄和血压是 CIMT 和 PWV 的独立决定因素，而体重指数和 LDL-胆固醇仅是 CIMT 的独立决定因素。 结论 这些观察结果表明，在健康年轻人中，动脉僵硬度和 CIMT 反映了血管损伤的两个独立实体。
Background Previous reports have shown that carotid intima-media thickness (CIMT) and arterial stiffness are strong predictors of subsequent cardiovascular disease (CVD) morbidity and mortality, and are well related to an unfavourable cardiovascular risk profile in middle-aged and older subjects. These similarities suggest that arterial stiffness may play a role in the development of atherosclerosis or vice versa. However, studies show conflicting results and are limited to elderly subjects. To study this issue further, we evaluated the relation of arterial stiffness to subclinical atherosclerosis in 524 healthy young adults, aged 27-30 years.Methods and Results Aortic stiffness was assessed using pulse wave velocity (PWV) and CIMT was used as measure of subclinical atherosclerosis. The positive crude correlation between for mean arterial pressure adjusted PWV and CIMT (Pearson's correlation coefficient: 0.11; P = 0.016) attenuated after adjustment for common determinants of both measurements like gender and age (partial correlation coefficient: 0.03; P = 0.512). Furthermore, multivariate linear regression models showed that male gender, age and blood pressure were independent determinants of both CIMT and PWV while body mass index and LDL-cholesterol were independent determinants of CIMT only.Conclusions These observations suggest that in healthy young adults arterial stiffness and CIMT reflect two separate entities of vascular damage.